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Journal Article (10)
Presentation (24)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Journal Article The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. None Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The MicroPhysiology Systems Database for analyzing and modeling compound interactions with human and animal organ models. Applied In Vitro Toxicology 2016;2(2):103-117. R835736 (2015)
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Journal Article “Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems”, Exp Biol Med (Maywood). None Lee-Montiel FT, George SM, Gough AH,Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL. “Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. Exp Biol Med 2017;242(16):1617-1632. R835736C004 (2018)
Journal Article A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX LAB ON A CHIP Li X, George SM, Vernetti L, Gough AH, Taylor DL Li X, George SM, Vernetti L, Gough AH, Taylor DL. A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab on a Chip 2018;21;18(17):2614-2631 R835736C004 (2018)
Journal Article Fluorescent protein biosensors applied to microphysiological systems. EXPERIMENTAL BIOLOGY AND MEDICINE Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL. Fluorescent protein biosensors applied to microphysiological systems. Experimental Biology and Medicine 2015;240(6):795-808. R835736 (2015)
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Journal Article Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems. EXPERIMENTAL BIOLOGY AND MEDICINE Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP. Pre-clinical and clinical investigations of metabolic zonation in liver diseases: the potential of microphysiology systems. Experimental Biology and Medicine 2017;242(16):1605-1616. R835736 (2017)
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Journal Article A human liver microphysiology platform for investigating physiology, drug safety, and disease models. EXPERIMENTAL BIOLOGY AND MEDICINE Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Experimental Biology and Medicine 2016;241(1):101-114. R835736 (2015)
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Journal Article Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. None Vernetti LA, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA,Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J,Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M,Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). R835736 (2017)
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Journal Article Evolution of experimental models of the liver to predict human drug hepatotoxicity and efficacy. None Vernetti LA, Vogt A, Gough A, Taylor DL Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of experimental models of the liver to predict human drug hepatotoxicity and efficacy. Clinics in Liver Disease 2017;21(1):197-214. R835736 (2015)
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Journal Article Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. None Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). R835736C004 (2017)
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R835738C002 (2016)
Journal Article Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. SCIENTIFIC REPORTS Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). R835736 (2015)
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R835738 (2016)
R835738C003 (2017)
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Presentation Evolution of a human liver MPS platform. None Taylor DL Taylor DL. Evolution of a human liver MPS platform. Presented at the Society for Experimental Biology and Medicine (SEBM) Annual Meeting, Chicago, IL, April 24, 2017. R835736 (2017)
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Presentation Spatial tumor biology for phenotyping, immunotyping and recapitulating tumor microenvironments. None Taylor DL Taylor DL. Spatial tumor biology for phenotyping, immunotyping and recapitulating tumor microenvironments. Presented at the Melanoma Specialized Programs of Research Excellence (SPORE) Meeting at the University of Pittsburgh, Pittsburgh, PA, August 2017. R835736 (2017)
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Presentation Functional application of liver organotypic culture models. None Taylor DL, Vernetti LA Taylor DL, Vernetti LA. Functional application of liver organotypic culture models. Presented via the EPA Virtual Tissue Models Meeting Webinar, February 22, 2017. R835736 (2017)
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Presentation Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. None Taylor DL Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented at the Eli Lilly meeting, Indianapolis, IN, July 24, 2017. R835736 (2017)
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Presentation The evolution, challenges and recent application of high content screening. None Taylor DL Taylor DL. The evolution, challenges and recent application of high content screening. Presented at the Servier Pharmaceutical Company Presentation, Paris, France, June 9, 2017. R835736 (2017)
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Presentation The next technology wave: biosensors, extreme computing, and organ chips for predicting cardiovascular toxicity. None Taylor DL Taylor DL. The next technology wave: biosensors, extreme computing, and organ chips for predicting cardiovascular toxicity. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. R835736 (2017)
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Presentation Quantitative systems pharmacology of liver diseases: human liver microphysiology system (MPS). None Taylor DL Taylor DL. Quantitative systems pharmacology of liver diseases: human liver microphysiology system (MPS). Presented at the Astra-Zeneca Review of AZ MPS Program, Boston, MA, March 23, 2017. R835736 (2017)
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Presentation Evolution of a human liver microphysiology system. None Taylor DL Taylor DL. Evolution of a human liver microphysiology system. Presented at the National Center for Advancing Translational Sciences (NCATS), The National Institues of Health, Bethesda, MD, May 5, 2017. R835736 (2017)
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Presentation The application of quantitative systems pharmacology to investigate liver diseases and toxicology. None Taylor DL Taylor DL. The application of quantitative systems pharmacology to investigate liver diseases and toxicology. Presented at the Tsinghua Seminar, Pittsburgh, PA, May 8, 2017. R835736 (2017)
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Presentation Investigating human liver disease progression with 3D microfluidic models. None Taylor DL Taylor DL. Investigating human liver disease progression with 3D microfluidic models. Presented at the High-Content Analysis and Phenotypic Screening Conference, Boston, MA, November 6, 2017. R835736 (2017)
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Presentation [title not provided]. None Taylor DL Taylor DL. [title not provided]. Presented at the National Academy of Sciences Roundtable, Washington, DC, October 5, 2017. R835736 (2017)
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Presentation A human liver-on-a-chip as a key experimental component of the application of quantitative systems pharmacology. None Taylor DL, Gough A Taylor DL, Gough A. A human liver-on-a-chip as a key experimental component of the application of quantitative systems pharmacology. Presented at the Roche Seminar, Basel, Switzerland, October 6, 2017. R835736 (2017)
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Presentation Quantitative systems pharmacology (QSP) in drug discovery. None Taylor DL Taylor DL. Quantitative systems pharmacology (QSP) in drug discovery. Presented at the NCI Online Principles of Clinical Pharmacology Course, Pittsburgh, PA, September 18, 2017. R835736 (2017)
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Presentation Metastatic breast cancer explored in a human, 3D, microfluidic liver chip. None Taylor DL Taylor DL. Metastatic breast cancer explored in a human, 3D, microfluidic liver chip. Presented at the Charles River Conference, Boston, MA, September 26, 2017. R835736 (2017)
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Presentation Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. None Taylor DL Taylor DL. Role of human liver microphysiology systems as part of a quantitative systems pharmacology platform for investigating ADMET and liver disease progression. Presented via the Health and Environmental Sciences Institute Webinar, September 5, 2017. R835736 (2017)
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Presentation A Human Liver Microphysiology System for Drug Discovery and development None Taylor DL Taylor, DL. A Human Liver Microphysiology System for Drug Discovery and development. Presented at North American meeting of the International Society for the Study of Xenobiotics, Montreal, Canada. July 16th-18, 2018. R835736C004 (2018)
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Presentation Application of quantitative systems pharmacology (QSP) and human microphysiology systems (MPS) to develop therapeutic strategies for liver disease None Taylor DL Taylor, DL. Application of quantitative systems pharmacology (QSP) and human microphysiology systems (MPS) to develop therapeutic strategies for liver diseases, Lawrenceville, New Jersey. October 26, 2018. R835736C004 (2018)
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Presentation Human Microphysiology Systems as a Critical Component of Quantitative Systems Pharmacology Applied to Drug Discovery and Development None Taylor DL Taylor, DL. Human Microphysiology Systems as a Critical Component of Quantitative Systems Pharmacology Applied to Drug Discovery and Development. Presented at DILI Sym Meeting, Chapel Hill, North Carolina. September 11, 2018. R835736C004 (2018)
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Presentation The Evolution of Human Experimental Models for Drug Discovery/Development and Precision medicine:Different Model Types, Reproducibility, Applications and Future Impact None Taylor, DL Taylor DL. The Evolution of Human Experimental Models for Drug Discovery/Development and Precision medicine:Different Model Types, Reproducibility, Applications and Future Impact. Presented at NIH workshop, Pittsburgh, Pennsylvania. September 13th-14th, 2018. R835736C004 (2018)
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Presentation Development of an integrated liver microphysiological system. None Vernetti LA Vernetti LA. Development of an integrated liver microphysiological system. Presented at the 20th North American International Society for the Study of Xenobiotics (ISSX) Meeting, Orlando, FL, October 18-22, 2015. R835736 (2016)
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Presentation Predicting human toxicity from MOA based high content imaging in 2D and 3D microphysiology systems. None Vernetti LA Vernetti LA. Predicting human toxicity from MOA based high content imaging in 2D and 3D microphysiology systems. Presented at Thermo Fisher, Princeton, NJ, October 13, 2016. R835736 (2016)
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Presentation The Human Liver Acinus MicroPhysiology System (LAMPS) for Analyzing and Ranking the Hepatotoxicity Potential of Compounds and as a Metabolic Component for Integration with other OCM None Vernetti LA, Gough A, Bergenthal L,Karcher S, Shun T, Wolter Q, Gavlock D, Reese C, Schurdak M, Taylor DL Vernetti LA, Gough A, Bergenthal L, Karcher S, Shun T, Wolter Q, Gavlock D, Reese C, Schurdak M, Taylor DL. Poster Presentation:The Human Liver Acinus MicroPhysiology System (LAMPS) for Analyzing and Ranking the Hepatotoxicity Potential of Compounds and as a Metabolic Component for Integration with other OCM. Presented at 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Reviews. May 22 and 23, 2018. R835736C004 (2018)
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Presentation Application and challenges to constructing a competent human liver on a chip. None Vernetti L Vernetti L. Application and challenges to constructing a competent human liver on a chip. Presented at the Society of Toxicology 2016 Satellite Meeting 3D or Not 3D: That is the [Predictive Toxicology] Question, New Orleans, LA, March 17, 2016 (invited). R835736 (2016)
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Presentation June 10th-15, 2018. None Taylor, DL, Gordon Research Conference on Toxicology, “Functional Coupling of Liver Microphysiological Systems,” Easton, Massachusetts Taylor, DL, Gordon Research Conference on Toxicology, “Functional Coupling of Liver Microphysiological Systems,” Easton, Massachusetts. June 10th-15, 2018. ". R835736C004 (2018)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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