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Grantee Research Project Results

Journal Publications Details for Grant Number R835164

In Vitro to In Vivo Screening of Thyroid Hormone Receptor Disrupting Chemicals

RFA: Developing High-Throughput Assays for Predictive Modeling of Reproductive and Developmental Toxicity Modulated Through the Endocrine System or Pertinent Pathways in Humans and Species Relevant to Ecological Risk Assessment (2011)

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Journal Article (5)
Reference Type Citation Progress Report Year Document Sources
Journal Article Freitas J, Miller N, Mengeling BJ, Xia M, Huang R, Houck K, Rietjens IM, Furlow JD, Murk AJ. Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Current Chemical Genomics and Translational Medicine 2014;8:36-46. R835164 (2012)
R835164 (Final)
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Journal Article Mengeling BJ, Furlow JD. Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses. Toxicology in Vitro 2015;29(7):1609-1618. R835164 (2012)
R835164 (Final)
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Journal Article Mengeling BJ, Murk AJ, Furlow JD. Trialkyltin rexinoid-X receptor agonists selectively potentiate thyroid hormone induced programs of Xenopus laevis metamorphosis. Endocrinology 2016;157(7):2712-2723. R835164 (Final)
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Journal Article Mengelinga BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquatic Toxicology 2017;190:1-10. R835164 (Final)
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Journal Article Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the elusive benzofuran impurity of the THR antagonist NH-3: synthesis, isotope labeling, and biological activity. Journal of Organic Chemistry 2016;81(5):1870-1876. R835164 (Final)
R835550 (Final)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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