Grantee Research Project Results
Journal Publications Details for Grant Number R835163
High Information Content Toxicity Screening Using Mouse and Human Stem Cell Models of Endocrine Development and Function
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Journal Article | Agopian AJ, Bhalla AD, Boerwinkle E, Finnell RH, Grove ML, Hixson JE, Shimmin LC, Sewda A, Stuart C, Zhong Y, Zhu H, Mitchell LE. Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida. Birth Defects Research Part A: Clinical and Molecular Teratology 2013;97(9):597-601. |
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| Journal Article | Cabrera RM, Finnell RH, Zhu H, Shaw GM, Wlodarczyk BJ. Transcriptional analyses of two mouse models of spina bifida. Birth Defects Research Part A: Clinical and Molecular Teratology 2012;94(10):782-789. |
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| Journal Article | Denny KJ, Coulthard LG, Jeanes A, Lisgo S, Simmons DG, Callaway LK, Wlodarczyk B, Finnell RH, Woodruff TM, Taylor SM. C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. Journal of Immunnology 2013;190(7):3493-3499. |
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| Journal Article | Denny KJ, Coulthard LG, Finnell RH, Callaway LK, Taylor SM, Woodruff TM. Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology 2013;97(2):211-216. |
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| Journal Article | Denny KJ, Jeanes A, Fathe K, Finnell RH, Taylor SM, Woodruff TM. Neural tube defects, folate, and immune modulation. Birth Defects Research Part A: Clinical and Molecular Teratology 2013;97(9):602-609. |
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| Journal Article | Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM. Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology 2016;106(3):201-207. |
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| Journal Article | Farkas SA, Bottiger AK, Isaksson HS, Finnell RH, Ren A, Nilsson TK. Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia. Epigenetics 2013;8(3):303-316. |
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| Journal Article | Fathe K, Palacios A, Finnell RH. Brief report novel mechanism for valproate-induced teratogenicity. Birth Defects Research Part A: Clinical and Molecular Teratology 2014;100(8):592-597. |
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| Journal Article | Gulvady AA, Murphy EJ, Ciolino HP, Cabrera RM, Jolly CA. Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice. Lipids 2013;48(1):3-12. |
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| Journal Article | Gulvady AA, Ciolino HP, Cabrera RM, Jolly CA. Resveratrol inhibits the deleterious effects of diet-induced obesity on thymic function. The Journal of Nutritional Biochemistry 2013;24(9):1625-1633. |
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| Journal Article | Hansler A, Chen Q, Gray JD, Ross ME, Finnell RH, Gross SS. Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects. Birth Defects Research Part A: Clinical and Molecular Teratology 2014;100(8):623-632. |
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| Journal Article | Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M. Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus. Journal of Medicinal Chemistry 2013;56(16):6467-6477. |
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| Journal Article | Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A. LRP2 mediates folate uptake in the developing neural tube. Journal of Cell Science 2014;127(Pt 10):2261-2268. |
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| Journal Article | Lai S-C, Nakayama Y, Sequeira JM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Bottiglieri T, Quadros EV. The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. FASEB Journal 2013;27(6):2468-2475. |
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| Journal Article | Lei Y, Zhu H, Duhon C, Yang W, Ross ME, Shaw GM, Finnell RH. Mutations in planar cell polarity gene SCRIB are associated with spina bifida. PLoS One 2013;8(7):e69262 (8 pp.). |
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| Journal Article | Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Identification of novel CELSR1 mutations in spina bifida. PLoS One 2014;9(3):e92207 (8 pp.). |
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| Journal Article | Lupo PJ, Canfield MA, Chapa C, Lu W, Agopian AJ, Mitchell LE, Shaw GM, Waller DK, Olshan AF, Finnell RH, Zhu H. Diabetes and obesity-related genes and the risk of neural tube defects in the National Birth Defects Prevention Study. American Journal of Epidemiology 2012;176(12):1101-1109. |
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| Journal Article | Lupo PJ, Chapa C, Nousome D, Duhon C, Canfield MA, Shaw GM, Finnell RH, Zhu H; National Birth Defects Prevention Study. A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study. Molecular Genetics and Metabolism 2012;107(3):592-595. |
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| Journal Article | Lupo PJ, Mitchell LE, Canfield MA, Shaw GM, Olshan AF, Finnell RH, Zhu H, National Birth Defects Prevention Study. Maternal-fetal metabolic gene-gene interactions and risk of neural tube defects. Molecular Genetics and Metabolism 2014;111(1):46-51. |
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| Journal Article | Martinez-Una M, Varela-Rey M, Cano A, Fernandez-Ares L, Beraza N, Aurrekoetxea I, Martinez-Arranz I, Garcia-Rodriguez JL, Buque X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martinez-Chantar ML, Aspichueta P, Mato JM. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. Hepatology 2013;58(4):1296-1305. |
R835163 (Final) |
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| Journal Article | Martinez-Una M, Varela-Rey M, Mestre D, Fernandez-Ares L, Fresnedo O, Fernandez-Ramos D, Gutierrez-de Juan V, Martin-Guerrero I, Garcia-Orad A, Luka Z, Wagner C, Lu SC, Garcia-Monzon C, Finnell RH, Aurrekoetxea I, Buque X, Martinez-Chantar ML, Mato JM, Aspichueta P. S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease. Journal of Hepatology 2015;62(3):673-681. |
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| Journal Article | Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH. Rfx2 is required for spermatogenesis in the mouse. Genesis 2015;53(9):604-611. |
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| Journal Article | Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M. Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. Epilepsia 2014;55(12):1944-1952. |
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| Journal Article | Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M. Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential. Epilepsia 2014;55(2):353-361. |
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| Journal Article | Tabler JM, Barrell WB, Szabo-Rogers HL, Healy C, Yeung Y, Perdiguero EG, Schulz C, Yannakoudakis BZ, Mesbahi A, Wlodarczyk B, Geissmann F, Finnell RH, Wallingford JB, Liu KJ. Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes. Developmental Cell 2013;25(6):623-635. |
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| Journal Article | Tsurubuchi T, Allender EV, Siddiqui MR, Shim KW, Ichi S, Boshnjaku V, Mania-Farnell B, Xi G, Finnell RH, McLone DG, Tomita T, Mayanil CS. A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8-/- embryos. Child's Nervous System 2014;30(8):1343-1353. |
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| Journal Article | Wallingford JB, Niswander LA, Shaw GM, Finnell RH. The continuing challenge of understanding, preventing, and treating neural tube defects. Science 2013;339(6123):1222002 (7 pp.). |
R835163 (Final) |
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| Journal Article | Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang LL, Zhang Y, Wang X, Tao S, Finnell RH. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environmental Science & Technology 2015;49(1):588-596. |
R835163 (Final) |
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| Journal Article | Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang LL, Zhang Y, Wang X, Tao S, Finnell RH. Correction to levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environmental Science & Technology 2015;49(17):10754-10755. |
R835163 (Final) |
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| Journal Article | Wang X, Cabrera RM, Li Y, Miller DS, Finnell RH. Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. FASEB Journal 2013;27(3):1167-1175. |
R835163 (Final) |
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| Journal Article | Wlodarczyk BJ, Zhu H, Finnell RH. Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity. Toxicology and Applied Pharmacology 2014;275(1):22-27. |
R835163 (Final) |
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| Journal Article | Wlodarczyk B, Spiegelstein O, Hill D, Le XC, Finnell RH. Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.Toxicology Letters 2012;215(3):214-218. |
R835163 (Final) |
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| Journal Article | Yi D, Yuan Y, Jin L, Zhou G, Zhu H, Finnell RH, Ren A. Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population. Neurotoxicology 2015;46:73-78. |
R835163 (Final) |
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| Journal Article | Yuan Y, Jin L, Wang L, Li Z, Zhang L, Zhu H, Finnell RH, Zhou G, Ren A. Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population. Reproductive Toxicology 2013;37:70-75. |
R835163 (Final) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.