Grantee Research Project Results
Final Report: New Environmental Public Health Indicator Linking Organochlorine Compounds and Type 2 Diabetes
EPA Grant Number: R834795Title: New Environmental Public Health Indicator Linking Organochlorine Compounds and Type 2 Diabetes
Investigators: Chambers, Janice E. , Crow, John Allen , Ross, Matthew K. , Wills, Robert W.
Institution: Mississippi State University
EPA Project Officer: Hahn, Intaek
Project Period: April 1, 2011 through March 31, 2014 (Extended to March 31, 2016)
Project Amount: $500,000
RFA: Exploring Linkages Between Health Outcomes and Environmental Hazards, Exposures, and Interventions for Public Health Tracking and Risk Management (2009) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health
Objective:
This project was designed to develop an environmental public health indicator (EPHI) by studying the linkage between soil residues of organochlorine (OC) insecticides and their stable metabolites/degradates, levels of these compounds in people and a disease with which they are implicated, type 2 diabetes (T2D). The proposed EPHI would be serum levels of these OC compounds. There were two hypotheses: (1) Environmental (soil) levels of OC compounds and serum levels of these compounds in people residing in a region of intense agriculture (Mississippi Delta region) are greater than levels in soil and people from a less intensely farmed region (non-Delta region). (2) A quantitative relationship exists between serum levels of OC compounds and the prevalence of endocrine disorders of glucose metabolism (T2D/prediabetes/increased insulin resistance). The Mississippi Delta region was selected for study because of the historical use of high levels of OC insecticides (primarily in the 1950s and 1960s, prior to the banning of most OC insecticides in the 1970s) and because the prevalence of T2D and many other health, economic and social disparities is elevated in Deltans compared to most other populations in the United States.
Summary/Accomplishments (Outputs/Outcomes):
Region
|
DDE ng/g soil
|
Number of Detects
|
% Detects
|
Delta
|
340
|
40
|
67
|
Non-Delta
|
31
|
14
|
23
|
Group
|
N
|
Detects
|
Mean DDE, ng/g Lipid
|
Range DDE, ng/g Lipid
|
|
N
|
%
|
||||
Normal
|
140
|
99
|
70
|
1,231
|
8–9,365
|
T2D
|
160
|
124
|
78
|
1,251
|
10–14,391
|
|
|||||
Delta
|
150
|
117
|
78
|
1,466
|
8–10,572
|
Non-Delta
|
150
|
107
|
71
|
997
|
10–14,391
|
|
|||||
African-American
|
141
|
108
|
77
|
1,713
|
8–14,391
|
Caucasian
|
159
|
116
|
73
|
803
|
10–3,166
|
Group
|
N
|
Detects
|
Mean DDE, ng/g Lipid
|
|
N
|
%
|
|||
Delta normal
|
72
|
54
|
75
|
1,784
|
Non-Delta normal
|
68
|
47
|
69
|
595
|
|
||||
Delta T2D
|
78
|
63
|
81
|
1,192
|
Non-Delta T2D
|
82
|
60
|
73
|
1,311
|
|
Normal
|
Type 2 Diabetes
|
All
|
||||||
N
|
Mean
|
StDev
|
N
|
Mean
|
StDev
|
N
|
Mean
|
StDev
|
|
Height (In)
|
138
|
1.8
|
0.17
|
162
|
1.8
|
0.1
|
300
|
1.8
|
0.1
|
Weight(Kg)
|
138
|
93.4
|
20.5
|
162
|
102.0
|
21.2
|
300
|
98.0
|
21.2
|
BMI
|
138
|
29.3
|
5.9
|
162
|
32.1
|
6.7
|
300
|
30.8
|
6.5
|
Waist (In)
|
138
|
40.8
|
6.5
|
162
|
43.4
|
5.9
|
300
|
42.2
|
6.3
|
Age
|
138
|
65.5
|
11.1
|
162
|
66.4
|
10.0
|
300
|
66.0
|
10.5
|
Cholesterol
|
138
|
183.6
|
42.7
|
162
|
163.6
|
36.7
|
300
|
172.8
|
40.7
|
LDL
|
138
|
111.1
|
36.3
|
162
|
93.6
|
32.5
|
300
|
101.6
|
35.4
|
HDL
|
138
|
45.9
|
16.5
|
162
|
42.0
|
11.4
|
300
|
43.8
|
14.1
|
Triglycerides
|
138
|
144.5
|
86.3
|
162
|
157.1
|
98.1
|
300
|
151.3
|
92.9
|
A1C
|
79
|
5.8
|
0.5
|
162
|
7.5
|
1.5
|
241
|
7.0
|
1.5
|
Fasting Blood Glucose
|
134
|
100.5
|
15.4
|
162
|
147.9
|
55.7
|
296
|
126.4
|
48.6
|
|
Comparison
|
Units
|
Odds Ratio
|
90% CI
|
p Value
|
Age
|
Increasing
|
5 years
|
1.033
|
1.008–1.058
|
0.0301
|
BMI
|
Increasing
|
1 kg/m2
|
1.068
|
1.029–1.109
|
0.0034
|
DDE
|
Increasing
|
1000 ng/g L
|
|
|
0.1435
|
Delta
|
Yes versus No
|
|
|
|
0.9796
|
Hypertension
|
Yes versus No
|
|
2.893
|
1.697–4.932
|
0.0010
|
LDL group
|
High versus Normal
|
|
3.457
|
2.131–5.608
|
< 0.0001
|
Race
|
Black versus White
|
|
1.782
|
1.072–2.964
|
0.0615
|
DDE*Delta
|
|
|
|
|
0.0324
|
|
Comparison
|
Units
|
Odds ratio
|
90% CI
|
DDE in non-Delta
|
Increasing
|
1000 ng/g lipid
|
1.598
|
1.060–2.408
|
DDE in Delta
|
Increasing
|
1000 ng/g lipid
|
0.920
|
0.813–1.042
|
Conclusions:
Journal Articles on this Report : 1 Displayed | Download in RIS Format
Other project views: | All 9 publications | 1 publications in selected types | All 1 journal articles |
---|
Type | Citation | ||
---|---|---|---|
|
Meek E, Jones D, Crow J, Wills R, Cooke W, Chambers J. Association of serum levels of p,p'-Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi. Journal of Toxicology and Environmental Health-Part A-Current Issues 2019;82(6):387-400. |
R834795 (Final) |
Exit Exit |
Supplemental Keywords:
Analytical, environmental chemistry, exposure, health effects, human health, monitoring, persistent organic pollutants, public health, organochlorine compoundsProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- 2014 Progress Report
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
1 journal articles for this project