Grantee Research Project Results
2013 Progress Report: Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
EPA Grant Number: R834799C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834799
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
Investigators: Strickland, Matthew J , Russell, Armistead G. , Mulholland, James , Waller, Lance , Darrow, Lyndsey , Klein, Mitchel , Guensler, Randy , Davis, Robert , Liu, Yang
Current Investigators: Strickland, Matthew J , Russell, Armistead G. , Chang, Howard , Mulholland, James , Waller, Lance , Darrow, Lyndsey , Klein, Mitchel , Guensler, Randy , Liu, Yang
Institution: Emory University , Georgia Institute of Technology
Current Institution: Emory University , Georgia Institute of Technology , University of Nevada - Reno
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
Project Period Covered by this Report: August 1, 2012 through July 31,2013
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
In utero and early life experiences affect physiological development and can influence sensitivity to environmental factors throughout life. In this Project we explore the interplay between certain early life events, characterizations of air pollutant mixtures developed as part of the Center’s Mixtures Characterization Toolkit, and a range of pediatric health outcomes using two large, population-based birth cohorts. One cohort consists of roughly 1.7 million Georgia birth records that have been geocoded to the Census block level and linked with pediatric emergency department visits by staff at the Georgia Department of Human Resources. Using this statewide birth cohort, we are investigating acute effects of air pollution mixtures on respiratory health outcomes and ear infections in children, and we are assessing whether children who were born premature or low birth weight are more sensitive to ambient air pollutant concentrations than their counterparts. Further, we are using the statewide birth cohort to investigate whether ambient air pollutant mixtures during pregnancy are associated with the risk of preterm delivery or reduced birth weight. The second birth cohort is comprised of children who were members of the Kaiser Permanente Georgia Health Maintenance Organization in metropolitan Atlanta. In this birth cohort, where comprehensive medical and residential histories are available for each study subject, we will examine whether air pollutant mixtures during the first year of life are associated with the incidence of childhood asthma.
Progress Summary:
Future Activities:
The subcontract with Kaiser Permanente is now in place and creation of the historical birth cohort is underway. We will continue to construct the cohort during the next project year and we will hopefully be able to start epidemiological analyses in early 2014. Analyses of associations between air pollution and pediatric respiratory morbidity in Atlanta are wrapping up, as are analyses of air pollution and preterm delivery in the state-wide cohort, and manuscripts based on this work will be developed. Epidemiologic analyses utilizing the source apportionment estimates are slated to begin later in 2013. Model evaluation of the CMAQ-fused estimates should be completed in the next year, and development of the downscaled CMAQ estimates will begin later in 2013.
Journal Articles on this Report : 16 Displayed | Download in RIS Format
| Other subproject views: | All 91 publications | 39 publications in selected types | All 37 journal articles |
|---|---|---|---|
| Other center views: | All 338 publications | 139 publications in selected types | All 135 journal articles |
Supplemental Keywords:
ambient air, atmosphere, health effects, human health, susceptibility, vulnerability, sensitive populations, infants, children, risk, dose-response, cumulative effects, epidemiology, exposure, public policy, air quality modeling, monitoring, measurement methods, aerosol, particulates, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Southeast, Scientific Discipline, Health, Health Risk Assessment, Risk Assessments, Environmental Monitoring, Biochemistry, Atmospheric Sciences, children's health, particulate matter, ambient air monitoring, climate change, air pollution, airshed modeling, ambient particle health effects, susceptibility, human health riskRelevant Websites:
Southeastern Center for Air Pollution & Epidemiology (SCAPE) Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834799 The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2015 Progress Report
- 2014 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
37 journal articles for this subproject
Main Center: R834799
338 publications for this center
135 journal articles for this center