Grantee Research Project Results
Children's Environmental Health and Disease Prevention Research Centers: Formative Centers
EPA Grant Number: R834678Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers
Investigators: Woodruff, Tracey J. , Fisher, Susan J. , Steinauer, Jody , McMaster, Michael , Stotland, Naomi
Current Investigators: Woodruff, Tracey J. , Fisher, Susan J. , McMaster, Michael , Stotland, Naomi , Sutton, Patrice , Gerona, Roy
Institution: University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: May 5, 2010 through May 4, 2014
Project Amount: $762,983
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Our overall theme is to advance our understanding of how exposure to environmental chemicals affects early development using a new multidisciplinary approach that: 1) integrates epidemiologic and biomonitoring research on sources and exposures to environmental chemicals during pregnancy with basic biological research on how chemical exposures may disrupt early development; and 2) translates these scientific findings to community groups and healthcare providers in order to improve clinical care and prevent prenatal exposures to harmful chemicals. The Center will focus on Bisphenol A (BPA) as a model chemical for enhancing our general understanding of sources and exposures during the prenatal period and subsequent potential adverse health effects. Our objectives are to:
Assess the body burden of BPA in a geographically and socioeconomically diverse group of pregnant women and understand the role of intrauterine metabolism, developmental stage and placenta in influencing intrauterine exposures;
Investigate the relationship between exposure to BPA and early human development through development of an experimental in vitro cell model system ;
Identify sources of exposure to BPA in a geographically and socioeconomically diverse population of pregnant women; and
Mentor new researchers in the field of prenatal environmental health by partnering with community groups and health care providers to increase their capacity to prevent preconception and prenatal exposures to environmental hazards and to promote prevention‐oriented health policies.
Expected Results:
We expect, at the end of this project, to be able to 1) characterize sources of maternal exposure to BPA, the relationship between maternal and intrauterine levels of BPA and 2) gain an in‐depth understanding of BPA affects early development. We anticipate this will improve our ability to integrate the knowledge of enhanced exposures and susceptibilities we gain through this research into improved environmental health decision‐making.
Journal Articles: 11 Displayed | Download in RIS Format
| Other center views: | All 73 publications | 15 publications in selected types | All 11 journal articles |
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Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environmental Science & Technology 2013;47(21):12477-12485. |
R834678C001 (Final) R834678C003 (Final) |
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Robinson J, Hamilton E, Lam J, Chen H, Woodruff T. Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues. PLACENTA 2020;100:35-44. |
R834678 (Final) R835433 (Final) |
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Sutton P, Giudice LC, Woodruff TJ. Reproductive environmental health. Current Opinion in Obstetrics and Gynecology 2010;22(6):517-524. |
R834678 (2012) |
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Sutton P, Woodruff TJ, Vogel S, Bero LA. Conrad and Becker's "10 Criteria" fall short of addressing conflicts of interest in chemical safety studies. Environmental Health Perspectives 2011;119(12):A506-507. |
R834678 (2010) R834678 (2011) |
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Sutton P, Wallinga D, Perron J, Gottlieb M, Sayre L, Woodruff T. Reproductive health and the industrialized food system: a point of intervention for health policy. Health Affairs 2011;30(5):888-897. |
R834678 (2010) R834678 (2011) R834678 (2012) |
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Sutton P, Woodruff TJ, Conry J, Giudice LC. Toxic matters and fertility: what can a doctor do? San Francisco Medicine: Journal of the San Francisco Medical Society 2012;85(5)20-22. |
R834678 (2012) |
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Sutton P, Woodruff TJ, Perron J, Stotland N, Conry JA, Miller MD, Giudice LC. Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures. American Journal of Obstetrics and Gynecology 2012;207(3)164-173. |
R834678 (2010) R834678 (2011) R834678 (2012) |
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Sutton P, Woodruff TJ. Risk communication and decision tools for children's health protection. Birth Defects Research Part C: Embryo Today: Reviews 2013;99(1):45-49. |
R834678 (2012) |
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Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environmental Health 2014;13(1):25 (20 pp.). |
R834678C001 (Final) R835436 (2014) R835436 (2015) R835436 (2017) |
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Woodruff TJ, Sutton P, Navigation Guide Work Group. An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. Health Affairs 2011;30(5):931-937. |
R834678 (2010) R834678 (2011) R834678 (2012) |
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Woodruff TJ, Burke TA, Zeise L. The need for better public health decisions on chemicals released into our environment. Health Affairs 2011;30(5):957-967. |
R834678 (2011) |
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Supplemental Keywords:
risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods; Scientific Discipline, Health, RFA, Biology, Health Risk Assessment, Children's Health, Biochemistry, children's environmental health, assessment of exposure, prenatal exposure, biological response, Health, RFA, Scientific Discipline, Health Risk Assessment, Biology, Children's Health, Biochemistry, biological response, prenatal exposure, assessment of exposureProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.