Grantee Research Project Results
2009 Progress Report: Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
EPA Grant Number: R832416C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832416
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Harvard Particle Center
Center Director: Koutrakis, Petros
Title: Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
Investigators: Silverman, Frances , Gold, Diane R.
Current Investigators: Silverman, Frances , Gold, Diane R. , Urch, Bruce
Institution: University of Toronto
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2011)
Project Period Covered by this Report: August 1, 2008 through July 31,2009
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
- Acute human exposures to CAPs of coarse and fine size fractions result in cardiovascular responses including increased blood pressure (BP), vascular narrowing of the brachial artery diameter (BAD), vascular/autonomic dysfunction (impaired flow-mediated dilatation (FMD)), inflammation (respiratory and systemic), and oxidative stress compared to FA (control) exposures
- Respiratory inflammatory responses (induced sputum), pulmonary function (flow-volume curves) and nasal/respiratory symptom responses will be greater with coarse CAPs than fine CAPs, compared to FA .
- Associations between CAPs and cardiovascular responses will differ by particle size fraction and PM composition
Progress Summary:
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other subproject views: | All 8 publications | 5 publications in selected types | All 5 journal articles |
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Other center views: | All 206 publications | 199 publications in selected types | All 199 journal articles |
Type | Citation | ||
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Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension 2009;54(3):659-667. |
R832416 (2009) R832416C002 (2009) R832416C002 (2010) CR830837 (Final) |
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Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mittleman MA. Autonomic effects of controlled fine particulate exposure in young healthy adults:effect modification by ozone. Environmental Health Perspectives 2009;117(8):1287-1292. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R827353 (Final) |
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Thompson AM, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, Speck M, Brook JR, Manno M, Gold DR. Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen. Environmental Health Perspectives 2010;118(1):120-124. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R832416C002 (Final) CR830837 (Final) |
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Urch B, Speck M, Corey P, Wasserstein D, Manno M, Lukic KZ, Brook JR, Liu L, Coull B, Schwartz J, Gold DR, Silverman F. Concentrated ambient fine particles and not ozone induce a systemic interleukin-6 response in humans. Inhalation Toxicology 2010;22(3):210-218. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R832416C002 (Final) |
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Supplemental Keywords:
concentrated air particles, acute cardiovascular effects, coarse particles, fine particles, vascular dysfunction, inflammation, oxidative stress, RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, ambient air quality, atmospheric particulate matter, human health effects, chemical characteristics, automobile exhaust, airborne particulate matter, cardiovascular vulnerability, traffic related particulate matter, chemical composition, biological mechanism , biological mechanisms, human exposure, ambient particle health effects, mobile sources, autonomic dysfunction, oxidative stressRelevant Websites:
http://www.hsph.harvard.edu/epacenter/Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R832416 Harvard Particle Center Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832416C001 Cardiovascular Responses in the Normative Aging Study: Exploring the Pathways of Particle Toxicity
R832416C002 Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
R832416C003 Assessing Toxicity of Local and Transported Particles Using Animal Models Exposed to CAPs
R832416C004 Cardiovascular Effects of Mobile Source Exposures: Effects of Particles and Gaseous Co-pollutants
R832416C005 Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2010 Progress Report
- 2008 Progress Report
- 2007 Progress Report
- 2006 Progress Report
- Original Abstract
5 journal articles for this subproject
Main Center: R832416
206 publications for this center
199 journal articles for this center