Grantee Research Project Results
2008 Progress Report: Ultrafine Particles on and Near Freeways
EPA Grant Number: R832413C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R832413
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Ultrafine Particles on and Near Freeways
Investigators: Hinds, William C. , Cho, Arthur K. , Froines, John R. , Kleinman, Michael T.
Current Investigators: Hinds, William C. , Cho, Arthur K. , Froines, John R. , Kleinman, Michael T. , Zhu, Yifang
Institution: University of California - Los Angeles , University of Southern California
Current Institution: University of California - Los Angeles
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2012)
Project Period Covered by this Report: October 1, 2007 through September 30,2008
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
To determine the relative contributions of gaseous and particle components of ambient air samples to oxidative stress related health effects. Also, to obtain samples to assess the effect of age and freeze-thaw cycles on redox activity of the samples as measured by the DTT assay.
Progress Summary:
Project 5 consists of three subprojects that either directly or indirectly seek to improve our ability to assess health risk of air pollution by chemical and biological assays used by SCPC. Subproject 1 will obtain a large simultaneous sample of both particulate and gas phase contaminants from the same volume of air. Both phases will be used for the full slate of bioassays and detailed chemical analysis. Samples will be taken at different locations having a different mix of fresh , aged, and photochemically produced contaminants: an urban freeway site and a receptor site. We have completed the first phase sampling at UC Riverside and have started the second phase at an urban freeway site. Subproject 2 will provide concentrator capability for the Southern California Particle Center investigators and their projects. Work is continuing on testing and modifying the concentrator to make it suitable for our needs. Subproject 3 will use the concentrator to obtain particle samples at UCLA that will be analyzed by our DTT redox activity assay immediately after collection and after a series of aging and freeze-thaw cycles. The objective is to determine the effect of age and freeze-thaw cycles on redox activity of the samples as measured by the DTT assay.Future Activities:
Journal Articles on this Report : 2 Displayed | Download in RIS Format
Other subproject views: | All 34 publications | 13 publications in selected types | All 13 journal articles |
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Other center views: | All 241 publications | 157 publications in selected types | All 157 journal articles |
Type | Citation | ||
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Zhu Y, Eiguren-Fernandez A, Hinds WC, Miguel AH. In-cabin commuter exposure to ultrafine particles on Los Angeles freeways. Environmental Science & Technology 2007;41(7):2138-2145. |
R832413 (2008) R832413 (Final) R832413C005 (2007) R832413C005 (2008) R832413C005 (Final) R827352 (Final) |
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Zhu Y, Fung DC, Kennedy N, Hinds WC, Eiguren-Fernandez A. Measurements of ultrafine particles and other vehicular pollutants inside a mobile exposure system on Los Angeles freeways. Journal of the Air & Waste Management Association 2008;58(3):424-434. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C005 (2007) R832413C005 (2008) R832413C005 (Final) |
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Supplemental Keywords:
health effects, human health, sensitive populations, dose-response, enzymes, particulates, epidemiology, environmental chemistry, modeling,, RFA, Scientific Discipline, Health, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Ecology and Ecosystems, Ecological Risk Assessment, cardiopulmonary responses, chemical characteristics, human health effects, toxicology, airborne particulate matter, cardiovascular vulnerability, biological mechanism , biological mechanisms, chemical composition, traffic related particulate matter, ambient particle health effects, human exposure, respiratory impact, ultrafine particulate matter, mobile sources, PM, cardiotoxicity, oxidative stress, cardiovascular diseaseProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R832413 Southern California Children's Environmental Health Center Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832413C001 Contribution of Primary and Secondary PM Sources to Exposure & Evaluation of Their Relative Toxicity
R832413C002 Project 2: The Role of Oxidative Stress in PM-induced Adverse Health Effects
R832413C003 The Chemical Properties of PM and their Toxicological Implications
R832413C004 Oxidative Stress Responses to PM Exposure in Elderly Individuals With Coronary Heart Disease
R832413C005 Ultrafine Particles on and Near Freeways
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2011
- 2010 Progress Report
- 2009 Progress Report
- 2007 Progress Report
- 2006 Progress Report
- Original Abstract
13 journal articles for this subproject
Main Center: R832413
241 publications for this center
157 journal articles for this center