Grantee Research Project Results

Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study

EPA Grant Number: R827353C013
Subproject: this is subproject number 013 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
Investigators: Koutrakis, Petros
Current Investigators: Koutrakis, Petros , Wolfson, Jack M. , Lawrence, Joy , Ruiz, Pablo
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

Sources such as coal-fired power plants may produce only small quantities of primary particulate matter (PM), and most of the concern over the health impacts of power plant emissions focuses on the secondary particles formed via atmospheric oxidation of emitted SO2. The effects of secondary particles formed from vehicular emissions are also of considerable concern. However, toxicological studies of these secondary particles are difficult to carry out. The TERESA (Toxicological Evaluation of Realistic Emissions of Source Aerosols) study involves the use of mobile laboratories at power plants or sources of vehicular emissions to age these emissions, followed by animal exposures. Development of methods to carry out these studies was supported by the EPA PM Center at HSPH in conjunction with the Electric Power Research Institute and the US Department of Energy. Several power plants were included in the project to allow assessment of different coals and pollution control configurations. The primary goal of TERESA is to evaluate the comparative toxicity of secondary particles derived from coal-fired power plant emissions and vehicular sources.

Publications and Presentations:

Publications have been submitted on this subproject: View all 1 publications for this subproject | View all 207 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subproject | View all 204 journal articles for this center

Supplemental Keywords:

exposure, health effects, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring, air pollutants, air pollution, air quality, ambient air, ambient air monitoring, ambient air quality, ambient measurement methods, ambient monitoring, ambient particle health effects, ambient particles, animal inhalation study, assessment of exposure, biological mechanism, biological response, cardiopulmonary, cardiopulmonary response, cardiovascular disease, chemical exposure, children, developmental effects, dosimetry, environmental health hazard, exposure and effects, genetic susceptibility, health risks, human exposure, human health, human health effects, human health risk, human susceptibility, indoor air quality, indoor exposure, inhalation, inhalation toxicology, inhaled particles, lead, measurement methods, particle exposure, particulate exposure, particulates, pulmonary, pulmonary disease, respiratory, respiratory disease, risk assessment, sensitive populations, stratospheric ozone,, RFA, Scientific Discipline, Health, Air, particulate matter, Toxicology, Air Pollution Monitoring, Environmental Chemistry, air toxics, Air Pollution Effects, Risk Assessments, Environmental Monitoring, Molecular Biology/Genetics, indoor air, Children's Health, Environmental Engineering, Biology, particulates, health effects, microbiology, ambient air quality, chemical exposure, monitoring, risk assessment, sensitive populations, cardiopulmonary responses, epidemiology, human health effects, ambient air monitoring, indoor exposure, air pollutants, exposure and effects, ambient air, biological response, ambient measurement methods, pulmonary disease, developmental effects, respiratory disease, lead, air pollution, children, Human Health Risk Assessment, particle exposure, biological mechanism , ambient monitoring, mobile sources, inhalation, pulmonary, assessment of exposure, susceptibility, particulate exposure, ambient particle health effects, human exposure, environmental health hazard, epidemeology, inhalation toxicology, tropospheric ozone, PM, indoor air quality, cardiopulmonary, human health, modeling studies, air quality, respiratory, dosimetry, animal inhalation study, cardiovascular disease, genetic susceptibility, human health risk

Progress and Final Reports:

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.