Grantee Research Project Results
2003 Progress Report: Biomarkers and Neurobehavioral Effects of Perinatal Exposure to Chlorpyrifos and Other Organophosphate Insecticides
EPA Grant Number: R828611Title: Biomarkers and Neurobehavioral Effects of Perinatal Exposure to Chlorpyrifos and Other Organophosphate Insecticides
Investigators: Wilkins, John R. , Moeschberger, Melvin L. , Lindsay, Ronald L. , Weghorst, Christopher M. , Dietrich, Kim , Nishioka, M.
Current Investigators: Wilkins, John R. , Moeschberger, Melvin L. , Weghorst, Christopher M. , Dietrich, Kim , Nishioka, M.
Institution: The Ohio State University , University of Cincinnati , Wayne State University
Current Institution: The Ohio State University , Battelle Memorial Institute , University of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: February 12, 2001 through February 11, 2004 (Extended to February 11, 2006)
Project Period Covered by this Report: February 12, 2003 through February 11, 2004
Project Amount: $1,126,463
RFA: Biomarkers for the Assessment of Exposure and Toxicity in Children (2000) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The objective of this research project is to evaluate the putative relationship between perinatal exposure to chlorpyrifos as well as other organophosphate insecticides and the adverse neurobehavioral effects among infants and young children. This research project will employ biomarkers of exposure and susceptibility in a longitudinal design. Cohort ascertainment will involve the recruitment of 176 women in their second trimester of pregnancy into the longitudinal study, which will follow only healthy full-term newborns for 2 years.
Progress Summary:
Recruiting pregnant women into this 2-year study has proved to be more challenging than initially anticipated. Recruitment is still in progress. A total of 105 subjects have been recruited to date, but because of fetal complications and dropouts, 79 are enrolled actively. Sixty-five women have delivered their infants. Sixty-five women have provided second urine specimens and complete questionnaires. We have received 58 urine-soaked diapers from 2-month-old infants and have performed 54 Bayley Scales of Infant Development-II (BSID-II) on 3-month-old infants. We have received 35 diapers from 9-month-old infants and 12 urine-soaked diapers from 16-month-old infants. Twenty-eight infants have completed their first year in the study; blood samples have been obtained, centrifuged, aliquotted, and frozen. The next step is to continue recruitment and analysis of blood and urine specimens obtained thus far.
Future Activities:
We will aggressively recruit women into the study and obtain necessary biological specimens and questionnaire information during the next 6 months. As more infants are born, the effort will shift to receipt of biological specimens from infants as well as neurobehavioral assessments of infants. Analyses for insecticide metabolites will proceed as more samples are obtained.
Journal Articles:
No journal articles submitted with this report: View all 2 publications for this projectSupplemental Keywords:
infants, children, insecticides, biomarkers of exposure, susceptibility, health, biochemistry, children’s health, epidemiology, genetics, health risk assessment, molecular biology/genetics, susceptibility/sensitive population/genetic susceptibility, toxicology, adolescence, assessment of exposure, biological markers, biomarkers, children’s vulnerability, chlorpyrifos, developmental disorders, endocrine disruptors, environmental hazard exposures, exposure, genetic susceptibility, health effects, health risks, longitudinal study, measuring childhood exposure, neurobehavioral effects, neurotoxicity, organophosphate pesticides, perinatal exposure, sensitive populations, toxics,, RFA, Health, Scientific Discipline, Toxicology, Genetics, Health Risk Assessment, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Children's Health, genetic susceptability, Molecular Biology/Genetics, health effects, sensitive populations, infants, vulnerability, biomarkers, adolescence, health risks, chlorpyrifos, measuring childhood exposure, exposure, neurotoxicity, longitudinal study, endocrine disruptors, children, children's vulnerablity, assessment of exposure, insecticides, neurobehavioral effects, perinatanl exposure, biological markers, developmental disorders, genetic susceptibility, organophosphate pesticides, environmental hazard exposuresRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.