Grantee Research Project Results
2004 Progress Report: Biomarkers and Neurobehavioral Effects of Perinatal Exposure to Chlorpyrifos and Other Organophosphate Insecticides
EPA Grant Number: R828611Title: Biomarkers and Neurobehavioral Effects of Perinatal Exposure to Chlorpyrifos and Other Organophosphate Insecticides
Investigators: Wilkins, John R. , Moeschberger, Melvin L. , Weghorst, Christopher M. , Dietrich, Kim , Nishioka, M.
Institution: The Ohio State University , University of Cincinnati , Wayne State University
Current Institution: The Ohio State University , Battelle Memorial Institute , University of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: February 12, 2001 through February 11, 2004 (Extended to February 11, 2006)
Project Period Covered by this Report: February 12, 2004 through February 11, 2005
Project Amount: $1,126,463
RFA: Biomarkers for the Assessment of Exposure and Toxicity in Children (2000) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Using biomarkers of exposure and susceptibility in a longitudinal design, the objective of this research is to evaluate the putative relationship between adverse neurobehavioral effects in infants and young children and perinatal exposure to chlorpyrifos, diazinon, other organophosphate insecticides, and, as an important addition to the study protocol, pyrethroid insecticides. Cohort ascertainment requires recruitment of 176 women in their second trimester of a low-risk pregnancy into the longitudinal study that will follow only healthy, full-term newborns for 2 years.
Progress Summary:
Recruiting pregnant women into this study has proven to be much more challenging than initially anticipated; recruitment is still in progress. A total of 145 subjects has been recruited (i.e., consented) to date, but because of fetal complications and dropouts, 117 are actively enrolled. Ninety-seven women have delivered their infants, and 104 have provided second urine specimens and complete questionnaires. We have received 83 urine-soaked diapers from 2-month-old infants and have performed 80 Bayley Scales of Infant Development (BSID-II) on 3-month-old infants. We have received 70 diapers from 9-month-old infants, and 46 urine-soaked diapers from 16-month-old infants. Fifty-five infants have completed their first year in the study, blood samples have been obtained, centrifuged, aliquotted, and frozen. Twenty-nine urine-soaked diapers from 23-month-old infants have been received. We have performed 21 BSID-II on 24-month-old infants.
Future Activities:
The next 6 months will be devoted to recruiting women into the study aggressively and obtaining necessary biological specimens and questionnaire information. As more infants are born, the effort will shift to receipt of biological specimens from infants as well as neurobehavioral assessments of infants. Analyses for insecticide metabolites will proceed as more samples are obtained.
Journal Articles:
No journal articles submitted with this report: View all 2 publications for this projectSupplemental Keywords:
infants, children, insecticides, biomarkers of exposure, susceptibility, organophosphate pesticides, genetic susceptibility, chlorpyrifos, developmental disorders, endocrine disruptors, environmental hazard exposures, longitudinal study, neurobehavioral, neurotoxicity, perinatal exposure, sensitive populations, toxics, epidemiology, genetics,, RFA, Scientific Discipline, Health, Toxicology, Genetics, Health Risk Assessment, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Children's Health, Molecular Biology/Genetics, genetic susceptability, health effects, sensitive populations, infants, vulnerability, biomarkers, adolescence, health risks, chlorpyrifos, measuring childhood exposure, exposure, neurotoxicity, longitudinal study, endocrine disruptors, children, children's vulnerablity, assessment of exposure, insecticides, neurobehavioral effects, perinatanl exposure, biological markers, developmental disorders, genetic susceptibility, organophosphate pesticides, environmental hazard exposuresRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.