Grantee Research Project Results

Effects of Particle-Associated Irritants on the Cardiovascular System

EPA Grant Number: R827351C006
Subproject: this is subproject number 006 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2000 — 2005)
Center Director: Greenbaum, Daniel S.
Title: Effects of Particle-Associated Irritants on the Cardiovascular System
Investigators: Nadziejko, Christine
Institution: New York University School of Medicine
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The objective of this research project is to examine the cardiovascular effects of gaseous co-pollutants, in response to recent epidemiological studies which suggest that co-pollutant gases contribute to the cardiovascular effects of particulate matter (PM). The physical and chemical properties of PM responsible for cardiovascular health effects are currently unknown. This project is closely coordinated with another project directed by Dr. Chen, also part of the New York University (NYU) Environmental Protection Agency (EPA) PM Center. The same animal models and biological endpoints are used in both studies. However, the two projects differ in the exposure atmospheres that are being examined, so as to test different hypotheses regarding the biologically active components of PM.

Publications and Presentations:

Publications have been submitted on this subproject: View all 5 publications for this subproject | View all 112 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 5 journal articles for this subproject | View all 89 journal articles for this center

Supplemental Keywords:

particulate matter, PM, exposure, epidemiology, animal, rat, toxicology, organic irritant, cardiovascular, cardiac parameters, heart rate, electrocardiogram, ECG, arrythmia, hypertensive rat., RFA, Health, PHYSICAL ASPECTS, Scientific Discipline, Air, ENVIRONMENTAL MANAGEMENT, particulate matter, Environmental Chemistry, Health Risk Assessment, air toxics, Risk Assessments, Physical Processes, Environmental Monitoring, Atmospheric Sciences, Risk Assessment, ambient air quality, atmospheric particulate matter, particulates, atmospheric particles, chemical characteristics, toxicology, ambient air monitoring, acute cardiovascular effects, airborne particulate matter, environmental risks, exposure, epidemelogy, Sulfur dioxide, air pollution, aerosol composition, atmospheric aerosol particles, human exposure, PM, exposure assessment

Progress and Final Reports:

Main Center Abstract and Reports:

R827351 Health Effects Institute (2000 — 2005)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827351C001 Exposure Characterization Error
R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
R827351C003 Asthma Susceptibility to PM_2.5
R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
R827351C009 Health Risks of Particulate Matter Components: Center Service Core
R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
R827351C011 Urban PM_2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
R827351C013 Long Term Health Effects of Concentrated Ambient PM_2.5
R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
R827351C016 Automated Real-Time Ambient Fine PM Monitoring System

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.