Grantee Research Project Results
Final Report: A Longitudinal Approach of Assessing Aggregate Exposure to Organophosphorus Pesticides in Children
EPA Grant Number: R829364Title: A Longitudinal Approach of Assessing Aggregate Exposure to Organophosphorus Pesticides in Children
Investigators: Lu, Chensheng (Alex) , Fenske, Richard
Institution: University of Washington
EPA Project Officer: Aja, Hayley
Project Period: September 1, 2001 through August 31, 2005
Project Amount: $1,246,407
RFA: Aggregate Exposure Assessment for Pesticides: Longitudinal Case Studies (2001) RFA Text | Recipients Lists
Research Category: Pesticides , Safer Chemicals , Human Health
Objective:
The Children Pesticide Exposure Study (CPES) was designed to characterize children’s (ages 3-11) longitudinal exposure to pesticides due to the variations of dietary consumption. Two of the innovative ideas in the CPES study design were the incorporation of an organic diet intervention and the use of urinary biomarkers for assessing dietary pesticide exposure quantitatively.
Summary/Accomplishments (Outputs/Outcomes):
In brief, CPES was initially conducted in Seattle, Washington (CPES-WA), and repeated in Atlanta, Georgia (CPES-GA) from 2006 to 2007. We initially enrolled 23 and 22 children, and 19 and 20 of them eventually completed all four-study seasons of CPES-WA and CPES-GA, respectively. Study participants were enrolled for 12 consecutive months, spanning four seasons. Each CPES child participated in a 15- and 12-consecutive-day sampling period in the summer and fall seasons, respectively, and a 7-consecutive-day sampling period in the winter and spring seasons. In the summer and fall sampling seasons, a 5-consecutive-day organic diet substitution protocol was incorporated into the study design. No organic diet substitution was made during the winter and spring seasons.
Conclusions:
Journal Articles on this Report : 14 Displayed | Download in RIS Format
Other project views: | All 29 publications | 14 publications in selected types | All 14 journal articles |
---|
Type | Citation | ||
---|---|---|---|
|
Attfuekdm JR, Hugnes M, Spengler J, Lu C. Within-and Between-Child Variation in Repeated Urinary Pesticide Metabolite Measurements over a 1-Year Period. ENVIRONMENTAL HEALTH PERSPECTIVES 2014;122(2):201-206. |
R829364 (Final) |
|
|
Givens ML, Lu C, Bartell SM, Pearson MA. Estimating dietary consumption patterns among children:a comparison between cross-sectional and longitudinal study designs. Environmental Research 2007;103(3):325-330. |
R829364 (Final) R832244 (Final) |
Exit Exit Exit |
|
Lu C, Bravo R, Caltabiano LM, Irish RM, Weerasekera G, Barr DB. The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments. Journal of Toxicology and Environmental Health, Part A: Current Issues 2005;68(3):209-227. |
R829364 (Final) |
Exit |
|
Lu C, Toepel K, Irish R, Fenske RA, Barr DB, Bravo R. Organic diets: Lu et al. respond. Environmental Health Perspectives 2006;114(4):A211. |
R829364 (Final) |
|
|
Lu C, Toepel K, Irish R, Fenske RA, Barr DB, Bravo R. Organic diets significantly lower children's dietary exposure to organophosphorus pesticides. Environmental Health Perspectives 2006;114(2):260-263. |
R829364 (Final) |
Exit |
|
Lu C, Fenske RA, Barr DB. OP pesticides, organic diets, and children’s health: Lu et al. respond. Environmental Health Perspectives 2006;114(10):A572-A573. |
R829364 (Final) |
Exit |
|
Lu C, Barr DB, Pearson MA, Bartell S, Bravo R. A longitudinal approach to assessing urban and suburban children’s exposure to pyrethroid pesticides. Environmental Health Perspectives 2006;114(9):1419-1423. |
R829364 (Final) |
Exit |
|
Lu C, Barr DB, Pearson MA, Waller LA. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environmental Health Perspectives 2008;116(4):537-542. |
R829364 (Final) |
Exit |
|
Lu C, Barr DB, Pearson MA, Walker LA, Bravo R. The attribution of urban and suburban children’s exposure to synthetic pyrethroid pesticides: a longitudinal assessment. Journal of Exposure Science and Environmental Epidemiology 2009;19(1):69-78. |
R829364 (Final) |
Exit Exit Exit |
|
Lu C, Holbrook CM, Andres LM. The implications of using a physiologically based pharmacokinetic (PBPK) model for pesticide risk assessment. Environmental Health Perspectives 2010;118(1):125-130. |
R829364 (Final) R832244 (Final) |
Exit |
|
Lu C, Schenck FJ, Pearson MA, Wong JW. Assessing children’s dietary pesticide exposure: direct measurement of pesticide residues in 24-hr duplicate food samples. Environmental Health Perspectives 2010;118(11):1625-1630. |
R829364 (Final) R832244 (Final) |
Exit |
|
Pearson MA, Lu C, Schmotzer BJ, Waller LA, Riederer AM. Evaluation of physiological measures for correcting variation in urinary output:implications for assessing environmental chemical exposure in children. Journal of Exposure Science and Environmental Epidemiology 2009;19(3):336-342. |
R829364 (Final) R828606 (Final) R832244 (Final) |
Exit Exit Exit |
|
Riederer AM, Pearson MA, Lu C. Comparison of food consumption frequencies among NHANES and CPES children: implications for dietary pesticide exposure and risk assessment. Journal of Exposure Science and Environmental Epidemiology 2010;20(7):602-614. |
R829364 (Final) R832244 (Final) |
Exit |
|
Schenck F, Wong J, Lu C, Li J, Holcomb JR, Mitchell LM. Multiresidue analysis of 102 organophosphorus pesticides in produce at parts-per billion levels using a modified QuEChERS method and gas chromatography with pulsed flame photometric detection. Journal of AOAC International 2009;92(2):561-573. |
R829364 (Final) R832244 (Final) |
Exit |
Supplemental Keywords:
RFA, Health, Scientific Discipline, Toxics, Air, air toxics, pesticides, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, Biochemistry, Children's Health, genetic susceptability, pesticide exposure, rural communities, urban air, sensitive populations, monitoring, organophosphates, multi-pathway study, long term exposure, age-related differences, dermal contact, exposure, children, longitudinal study, gender-related variability, pesticide residues, insecticides, human exposure, environmental toxicant, neurotixics, dust , biological markers, dietary exposure, agricultural community, organophosphate pesticides, exposure assessment, environmental hazard exposuresProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.