Grantee Research Project Results

Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness

EPA Grant Number: R825702C012
Subproject: this is subproject number 012 , established and managed by the Center Director under grant R825702
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Denver Children’s Environmental Health Center - Environmental Determinants of Airway Disease in Children
Center Director: Schwartz, David A.
Title: Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
Investigators: Mason, Robert J.
Current Investigators: Gelfand, Erwin
Institution: National Jewish Medical and Research Center
EPA Project Officer: Chung, Serena
Project Period: February 16, 1998 through February 28, 2003 (Extended to February 28, 2004)
RFA: Environmental Lung Disease Center (National Jewish Medical and Research Center) (1998) RFA Text | Recipients Lists
Research Category: Targeted Research

Objective:

This core unit will provide the facility for exposing rodents to air pollutants both on site and off site. For short term exposure of easily monitored air pollutants such as ozone and nitrogen dioxide, this will be done in the animal facility at National Jewish. For long term inhalational exposures or exposures that are difficult to quantitate, such as particulates, we will perform collaborative studies off site. This core will contain funds to encourage and support inhalation exposures. However, this year we will use funds to construct the on site component. Although we considered several off site exposures, we felt that we needed more time to define our systems and the response to instilled particulates before embarking on expensive long-term inhalation exposures.

Function

This core will develop the exposure at National Jewish for short term exposures to ozone and nitrogen dioxide. The major function for this year is for construction to build the facility at National Jewish.

Quality Assurance

The exposure facility will be designed to produce reliable monitored defined exposures. The specifics of the exposures will be defined in the individual projects. All protocols will require review by the animal care facility and review by Dr. White. The animals will be housed in special isolators after the exposure.

Personnel

Dr. White will direct this core.

Publications and Presentations:

Publications have been submitted on this subproject: View all 24 publications for this subproject | View all 132 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 20 journal articles for this subproject | View all 110 journal articles for this center

Supplemental Keywords:

RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, Atmospheric Sciences, Biology, chemical exposure, Nitrogen dioxide, particulates, human health effects, animal model, ozone, exposure, air pollution, particle exposure, particle exposure models, environmental health effects, inhalation, human exposure, particulate exposure, exposure core, inhaled, PM, human health risk

Progress and Final Reports:

Main Center Abstract and Reports:

R825702 Denver Children’s Environmental Health Center - Environmental Determinants of Airway Disease in Children

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R825702C001 SP-A and SP-D in Environmental Lung Disease
R825702C003 Adaptation to Nitrogen Dioxide: Role of Altered Glycolytic Pathway Enzyme Expression and NF-κB-Dependent Cellular Defenses Against Apoptosis
R825702C005 Inhalation of Particulate Matter Alters the Allergic Airway Response to Inhaled Allergen
R825702C006 Particle-Induced Lung Inflammation and Extracellular EC-SOD
R825702C007 Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
R825702C008 The Role of Mitochondrial DNA Mutations in Oxidant-Mediated Lung Injury
R825702C009 Immunopathogenesis of Hypersensitivity Pneumonitis in the Mouse
R825702C010 Activation of Natural T Lymphocytes by Diesel Exhaust Particulates Leads to Their Production of Interleukin-4 and TH2 Lymphocyte Differentiation to Allergen
R825702C011 Latex Antigen Levels During Powdered and Powderless Glove Use
R825702C012 Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
R825702C013 Acute Exposure to Particulate Air Pollution in Childhood Asthma
R825702C014 Mechanisms of Ozone Toxicity to the Lung

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.