Grantee Research Project Results
Immunologic Basis of Environmental Lung Disease
EPA Grant Number: R825702Center: Denver Children’s Environmental Health Center - Environmental Determinants of Airway Disease in Children
Center Director: Schwartz, David A.
Title: Immunologic Basis of Environmental Lung Disease
Investigators: Mason, Robert J.
Current Investigators: Mason, Robert J. , White, Carl W. , Gelfand, Erwin , Rabinovitch, Nathan
Institution: National Jewish Medical and Research Center
EPA Project Officer: Chung, Serena
Project Period: February 16, 1998 through February 28, 2003 (Extended to February 28, 2004)
Project Amount: $7,269,177
RFA: Environmental Lung Disease Center (National Jewish Medical and Research Center) (1998) RFA Text | Recipients Lists
Research Category: Targeted Research
Objective:
The objectives of the Environmental Lung Disease Center are to improve the understanding of lung disease, and develop innovative early disease detection, prevention and treatment approaches. The center's research involves: 1) determining the molecular mechanisms of environmental and occupational lung disease, 2) identifying the genetic and molecular basis for individual susceptibility, and 3) identifying the risk and effects of air pollution on human population with preexisting pulmonary diseases, and the exposure/host response relationship that leads to disease. Besides immunologic diseases, the project will focus on respiratory, allergic, and infectious diseases, through an integrated program of basic and clinical research.Journal Articles: 110 Displayed | Download in RIS Format
Other center views: | All 132 publications | 111 publications in selected types | All 110 journal articles |
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Ahmad A, Ahmad S, Chang L-Y, Schaack J, White CW. Endothelial Akt activation by hyperoxia: role in cell survival. Free Radical Biology and Medicine 2006;40(7):1108-1118. |
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Ahmad S, Ahmad A, Ghosh M, Leslie CC, White CW. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. The Journal of Biological Chemistry 2004;279(16):16317-16325. |
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Ahmad S, Ahmad A, McConville G, Schneider BK, Allen CB, Manzer R, Mason RJ, White CW. Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radical Biology and Medicine 2005;39(2):213-226. |
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Ahmad S, Ahmad A, Schneider BK, White CW. Cholesterol interferes with the MTT assay in human epithelial-like (A549) and endothelial (HLMVE and HCAE) cells. International Journal of Toxicology 2006;25(1):17-23. |
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Allen CB. An automated system for exposure of cultured cells and other materials to ozone. Inhalation Toxicology 2003;15(10):1039-1052. |
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Allen MJ, Harbeck R, Smith B, Voelker DR, Mason RJ. Binding of rat and human surfactant proteins A and D to Aspergillus fumigatus conidia. Infection and Immunity 1999;67(9):4563-4569. |
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Allen MJ, Voelker DR, Mason RJ. Interactions of surfactant proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus. Infection and Immunity 2001;69(4):2037-2044. |
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Allen MJ, Laederach A, Reilly PJ, Mason RJ. Polysaccharide recognition by surfactant protein D: novel interactions of a C-type lectin with nonterminal glucosyl residues. Biochemistry 2001;40(26):7789-7798. |
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Allen MJ, Laederach A, Reilly PJ, Mason RJ, Voelker DR. Arg343 in human surfactant protein D governs discrimination between glucose and N-acetylglucosamine ligands. Glycobiology 2004;14(8):693-700. |
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Bin L-H, Nielson LD, Liu X, Mason RJ, Shu H-B. Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. The Journal of Immunology 2003;171(2):924-930. |
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Born WK, Lahn M, Takeda K, Kanehiro A, O'Brien RL, Gelfand EW. Role of γδ T cells in protecting normal airway function. Respiratory Research 2000;1(3):151-158. |
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Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. American Journal of Respiratory and Critical Care Medicine 2007;176(1):10-19. |
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Cui Z-H, Joetham A, Aydintug MK, Hahn Y-S, Born WK, Gelfand EW. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδ T cells. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1324-1332. |
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Dakhama A, Kanehiro A, Makela MJ, Loader JE, Larsen GL, Gelfand EW. Regulation of airway hyperresponsiveness by calcitonin gene-related peptide in allergen sensitized and challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(8):1137-1144. |
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Dakhama A, Kraft M, Martin RJ, Gelfand EW. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-β1 in airway epithelial cells by Mycoplasma pneumoniae. American Journal of Respiratory Cell and Molecular Biology 2003;29(3):344-351. |
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Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Current Opinion in Pharmacology 2004;4(3):215-220. |
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Dakhama A, Park J-W, Taube C, Chayama K, Balhorn A, Joetham A, Wei X-D, Fan R-H, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2004;170(9):952-959. |
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Dakhama A, Park J-W, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. American Journal of Physiology-Lung Cellular and Molecular Physiology 2005;288(4):L761-L770. |
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Dakhama A, Park J-W, Taube C, Joetham A, Balhorn A, Miyahara N, Takeda K, Gelfand EW. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus Is critically dependent on the age at first infection and IL-13 production. The Journal of Immunology 2005;175(3):1876-1883. |
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Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. The Journal of Immunology 1999;163(2):1019-1026. |
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Fontenot AP, Torres M, Marshall WH, Newman LS, Kotzin BL. Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12717-12722. |
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Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, Mason RJ. Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;280(1):L39-L49. |
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Fujita M, Shannon JM, Ouchi H, Voelker DR, Nakanishi Y, Mason RJ. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 2005;31(1):25-33. |
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Gelfand EW, Joetham A, Cui Z-H, Balhorn A, Takeda K, Taube C, Dakhama A. Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. Journal of Immunology 2004;173(2):1298-1306. |
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Gelfand EW, Dakhama A. CD8+ T lymphocytes and leukotriene B4: novel interations in the persistence and progression of asthma. Journal of Allergy and Clinical Immunology 2006;117(3):577-582. |
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Gelfand EW. Pediatric asthma: a different disease. Proceedings of the American Thoracic Society 2009;6(3):278-282. |
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Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2000;161(3):952-960. |
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Hahn Y-S, Taube C, Jin N, Sharp L, Wands JM, Aydintug MK, Lahn M, Huber SA, O'Brien RL, Gelfand EW, Born WK. Different potentials of γδT cell subsets in regulating airway responsiveness: Vγ1+ cells, but not Vγ4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation. The Journal of Immunology 2004;172(5):2894-2902. |
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Hamada K, Goldsmith C-A, Suzaki Y, Goldman A, Kobzik L. Airway hyperresponsiveness caused by aerosol exposure to residual oil fly ash leachate in mice. Journal of Toxicology and Environmental Health-Part A 2002;65(18):1351-1365. |
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Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. American Journal of Respiratory Cell and Molecular Biology 2000;23(3):327-334. |
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Hirano A, Kanehiro A, Ono K, Ito W, Yoshida A, Okada C, Nakashima H, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M. Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge. American Journal of Respiratory Cell and Molecular Biology 2006;35(3):366-377. |
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Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS. Toll-IL-1 receptor domain-containing adaptor protein Is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. The Journal of Immunology 2005;175(11):7484-7495. |
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Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. American Journal of Respiratory Cell and Molecular Biology 2005;32(6):531-539. |
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Jin N, Taube C, Sharp L, Hahn Y-S, Yin X, Wands JM, Roark CL, O'Brien RL, Gelfand EW, Born WK. Mismatched antigen prepares γδ T cells for suppression of airway hyperresponsiveness. The Journal of Immunology 2005;174(5):2671-2679. |
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Jin N, Miyahara N, Roark CL, French JD, Aydintug MK, Matsuda JL, Gapin L, O'Brien RL, Gelfand EW, Born WK. Airway hyperresponsiveness through synergy of γδ T cells and NKT cells. The Journal of Immunology 2007;179(5):2961-2968. |
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Joetham A, Takeda K, Taube C, Miyahara N, Kanehiro A, Dakhama A, Gelfand EW. Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge. American Journal of Respiratory Cell and Molecular Biology 2005;33(1):89-96. |
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Joetham A, Takada K, Taube C, Miyahara N, Matsubara S, Koya T, Rha YH, Dakhama A, Gelfand EW. Naturally occurring lung CD4+CD25+ T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β. The Journal of Immunology 2007;178(3):1433-1442. |
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Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15057-15062. |
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Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, Gelfand EW. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. The Journal of Immunology 2008;180(11):7117-7124. |
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Joetham A, Takeda K, Okamoto M, Taube C, Matsuda H, Dakhama A, Gelfand EW. Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells. The Journal of Immunology 2009;183(3):1821-1827. |
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Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG, Gelfand EW. Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. American Journal of Respiratory and Critical Care Medicine 2000;162(3):1132-1139. |
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Kanehiro A, Lahn M, Makela MJ, Dakhama A, Fujita M, Joetham A, Mason RJ, Born W, Gelfand EW. Tumor necrosis factor-α negatively regulates airway hyperresponsiveness through γδ T cells. American Journal of Respiratory and Critical Care Medicine 2001;164(12):2229-2238. |
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Kanehiro A, Ikemura T, Makela MJ, Lahn M, Joetham A, Dakhama A, Gelfand EW. Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. American Journal of Respiratory and Critical Care Medicine 2001;163(1):173-184. |
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Kanehiro A, Lahn M, Makela MJ, Dakhama A, Joetham A, Rha Y-H, Born W, Gelfand EW. Requirement for the p75 TNF-α receptor 2 in the regulation of airway hyperresponsiveness by γδ T cells. Journal of Immunology 2002;169(8):4190-4197. |
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Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW. Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. The Journal of Immunology 2007;178(1):480-488. |
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Kodama T, Kuribayashi K, Nakamura H, Fujita M, Fujita T, Takeda K, Dakhama A, Gelfand EW, Matsuyama T, Kitada O. Role of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma. Clinical and Experimental Immunology 2003;131(2):199-205. |
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Koya T, Takeda K, Kodama T, Miyahara N, Matsubara S, Balhorn A, Joetham A, Dakhama A, Gelfand EW. RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge. American Journal of Respiratory Cell and Molecular Biology 2006;35(2):147-154. |
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Koya T, Kodama T, Takeda K, Miyahara N, Yang ES, Taube C, Joetham A, Park JW, Dakhama A, Gelfand EW. Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. American Journal of Respiratory and Critical Care Medicine 2006;173(1):42-55. |
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Koya T, Matsuda JL, Takeda K, Matsubara S, Miyahara N, Balhorn A, Dakhama A, Gelfand EW. IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice. The Journal of Allergy and Clinical Immunology 2007;119(5):1241-1250. |
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Koya T, Miyahara N, Takeda K, Matsubara S, Matsuda H, Swasey C, Balhorn A, Dakhama A, Gelfand EW. CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4+IL-4+ T cells. The Journal of Immunology 2007;179(5):2787-2796. |
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Kumarathasan P, Blais E, Goegan P, Yagminas A, Guenette J, Adamson IY, Crapo JD, Mason RJ, Vincent R. 90-day repeated inhalation exposure of surfactant protein-C/tumor necrosis factor-α (SP-C/TNF-α) transgenic mice to air pollutants. International Journal of Toxicology 2005;24(1):59-67. |
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Lahn M, Kanehiro A, Takeda K, Terry J, Hahn Y-S, Aydintug MK, Konowal A, Ikuta K, O'Brien RL, Gelfand EW, Born WK. MHC class I-dependent Vγ4+ pulmonary T cells regulate αβT cell-independent airway responsiveness. Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8850-8855. |
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Larsen GL, White CW, Takeda K, Loader JE, Nguyen DDH, Joetham A, Groner Y, Gelfand EW. Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. American Journal of Physiology-Lung Cellular and Molecular Physiology 2000;279(2):L350-L359. |
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Lee NA, Gelfand EW, Lee JJ. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? The Journal of Allergy and Clinical Immunology 2001;107(6):945-957. |
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Lee Y-M, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-γ production during initial infection determines the outcome of reinfection with respiratory syncytial virus. American Journal of Respiratory and Critical Care Medicine 2008;177(2):208-218. |
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Lively TN, Kossen K, Balhorn A, Koya T, Zinnen S, Takeda K, Lucas JJ, Polisky B, Richards IM, Gelfand EW. Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice. The Journal of Allergy and Clinical Immunology 2008;121(1):88-94. |
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Maier LA, Raynolds MV, Young DA, Barker EA, Newman LS. Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease. American Journal of Respiratory and Critical Care Medicine 1999;159(4):1342-1350. |
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Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, Xing Z, Jordana M, Larsen GL, Gelfand EW. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6007-6012. |
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Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(6):824-831. |
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Makela MJ, Tripp R, Dakhama A, Park J-W, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW. Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. The Journal of Allergy and Clinical Immunology 2003;112(5):861-869. |
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Manzer R, Wang J, Nishina K, McConville G, Mason RJ. Alveolar epithelial cells secrete chemokines in response to IL-1β and lipopolysaccharide but not to ozone. American Journal of Respiratory Cell and Molecular Biology 2006;34(2):158-166. |
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Manzer R, Dinarello CA, McConville G, Mason RJ. Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha. American Journal of Respiratory Cell and Molecular Biology 2008;38(3):318-323. |
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Mason RJ. Biology of alveolar type II cells. Respirology 2006;11(Suppl 1):S12-S15. |
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Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, Masuda ES, Swasey CH, Gelfand EW. Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. American Journal of Respiratory Cell and Molecular Biology 2006;34(4):426-433. |
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Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, Miyahara N, Miyahara S, Lucas JJ, Dakhama A, Gelfand EW. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2006;173(1):56-63. |
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Matsubara S, Takeda K, Kodama T, Joetham A, Miyahara N, Koya T, Swasey CH, Okamoto M, Dakhama A, Gelfand EW. IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-γ, and natural killer cells. American Journal of Respiratory Cell and Molecular Biology 2007;36(3):324-332. |
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Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW. Estrogen determines sex differences in airway responsiveness after allergen exposure. American Journal of Respiratory Cell and Molecular Biology 2008;38(5):501-508. |
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Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T, Dakhama A, Ott VL, Gelfand EW. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nature Medicine 2004;10(8):865-869. |
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Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park J-W, Miyahara S, Balhorn A, Dakhama A, Gelfand EW. Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. The Journal of Immunology 2004;172(4):2549-2558. |
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Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, Gelfand EW. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. The Journal of Immunology 2005;174(8):4979-4984. |
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Miyahara N, Takeda K, Miyahara S, Matsubara S, Koya T, Joetham A, Krishnan E, Dakhama A, Haribabu B, Gelfand EW. Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2005;172(2):161-167. |
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Nishina K, Zhang F, Nielsen LD, Edeen K, Wang J, Mason RJ. Expression of CINC-2β is related to the state of differentiation of alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2005;33(5):505-512. |
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Ohnishi H, Miyahara N, Dakhama A, Takeda K, Mathis S, Haribabu B, Gelfand EW. Corticosteroids enhance CD8+ T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1. The Journal of Allergy and Clinical Immunology 2008;121(4):864-871. |
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Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW. Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. The Journal of Experimental Medicine 2008;205(5):1087-1097. |
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Pacheco KA, Tarkowski M, Sterritt C, Negri J, Rosenwasser LJ, Borish L. The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-β and IL-1β. Clinical and Experimental Immunology 2001;126(3):374-383. |
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Pan T, Nielsen LD, Allen MJ, Shannon KM, Shannon JM, Selman M, Mason RJ. Serum SP-D is a marker of lung injury in rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;282(4):L824-L832. |
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Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chemico-Biological Interactions 2004;147(1):87-97. |
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Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxidants & Redox Signaling 2004;6(1):129-136. |
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Panayiotidis MI, Stabler SP, Ahmad A, Pappa A, Legros Jr LH, Hernandez-Saavedra D, Schneider BK, Allen RH, Vasiliou V, McCord JM, Kotb M, White CW. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Radical Biology and Medicine 2006;40(2):348-358. |
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Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2009;674(1-2):23-30. |
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Park J-W, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Schultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2004;169(6):726-732. |
R825702 (Final) R825702C012 (Final) |
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Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW. Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. The Journal of Allergy and Clinical Immunology 2003;112(6):1078-1087. |
R825702 (Final) R825702C012 (Final) |
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Park J-W, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim S-H, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):830-836. |
R825702 (Final) R825702C012 (Final) |
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Pulfer MK, Taube C, Gelfand E, Murphy RC. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. Journal of Pharmacology and Experimental Therapeutics 2005;312(1):256-264. |
R825702 (Final) R825702C014 (Final) |
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Rabinovitch N, Zhang L, Murphy JR, Vedal S, Dutton SJ, Gelfand EW. Effects of wintertime ambient air pollutants on asthma exacerbations in urban minority children with moderate to severe disease. The Journal of Allergy and Clinical Immunology 2004;114(5):1131-1137. |
R825702 (Final) R825702C013 (Final) |
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Rabinovitch N, Liu AH, Zhang L, Rodes CE, Foarde K, Dutton SJ, Murphy JR, Gelfand EW. Importance of the personal endotoxin cloud in school-age children with asthma. The Journal of Allergy and Clinical Immunology 2005;116(5):1053-1057. |
R825702 (Final) R825702C013 (Final) |
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Rabinovitch N, Strand M, Gelfand EW. Particulate levels are associated with early asthma worsening in children with persistent disease. American Journal of Respiratory and Critical Care Medicine 2006;173(10):1098-1105. |
R825702 (Final) R825702C013 (Final) |
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Rabinovitch N, Liu AH, Zhang L, Foarde K, Rodes CE, Gelfand EW. Increased personal respirable endotoxin exposure with furry pets. Allergy 2006;61(5):650-651. |
R825702 (Final) R825702C013 (Final) |
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Rabinovitch N, Zhang L, Gelfand EW. Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction. The Journal of Allergy and Clinical Immunology 2006;118(3):635-640. |
R825702 (Final) |
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Rha Y-H, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. Journal of Immunology 2002;169(9):5300-5307. |
R825702 (Final) R825702C012 (Final) |
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Silkoff PE, Zhang L, Dutton S, Langmack EL, Vedal S, Murphy J, Make B. Winter air pollution and disease parameters in advanced chronic obstructive pulmonary disease panels residing in Denver, Colorado. The Journal of Allergy and Clinical Immunology 2005;115(2):337-344. |
R825702 (Final) |
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Strand M, Vedal S, Rodes C, Dutton SJ, Gelfand EW, Rabinovitch N. Estimating effects of ambient PM2.5 exposure on health using PM2.5 component measurements and regression calibration. Journal of Exposure Science and Environmental Epidemiology 2006;16(1):30-38. |
R825702 (Final) R825702C013 (Final) |
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Strand M, Hopke PK, Zhao W, Vedal S, Gelfand E, Rabinovitch N. A study of health effect estimates using competing methods to model personal exposures to ambient PM2.5 modeling personal exposures to PM2.5. Journal of Exposure Science and Environmental Epidemiology 2007;17(6):549-558. |
R825702 (Final) |
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Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. Journal of Biological Chemistry 2001;276(7):5093-5100. |
R825702 (Final) R825702C012 (Final) |
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Takeda K, Okamoto M, de Langhe S, Dill E, Armstrong M, Reisdorf N, Irwin D, Koster M, Wilder J, Stenmark KR, West J, Klemm D, Gelfand EW, Nozik-Grayck E, Majka SM. Peroxisome proliferator-activated receptor-γ agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 2009;292(7):1045-1061. |
R825702 (Final) |
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Taube C, Duez C, Cui Z-H, Takeda K, Rha YH, Park J-W, Balhorn A, Donaldson DD, Dakhama A, Gelfand EW. The role of IL-13 in established allergic airway disease. The Journal of Immunology 2002;169(11):6482-6489. |
R825702 (Final) |
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Taube C, Dakhama A, Rha Y-H, Takeda K, Joetham A, Park J-W, Balhorn A, Takai T, Poch KR, Nick JA, Gelfand EW. Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and FcγIII receptors. The Journal of Immunology 2003;170(8):4301-4309. |
R825702 (Final) |
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Taube C, Rha Y-H, Takeda K, Park J-W, Joetham A, Balhorn A, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1333-1341. |
R825702 (Final) |
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Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha Y-H, Park J-W, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):837-843. |
R825702 (Final) R825702C012 (Final) |
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Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW. Mast cells, FcεRI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. The Journal of Immunology 2004;172(10):6398-6406. |
R825702 (Final) |
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Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. The Journal of Immunology 2006;176(5):3157-3164. |
R825702 (Final) |
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Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation. Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8084-8089. |
R825702 (Final) |
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Taylor MD, Van Dyke K, Bowman LL, Miles PR, Hubbs AF, Mason RJ, Shannon K, Reasor MJ. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity. Toxicology and Applied Pharmacology 2000;167(3):182-190. |
R825702 (Final) R825702C001 (Final) |
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Tomkinson A, Cieslewicz G, Duez C, Larson KA, Lee JJ, Gelfand EW. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice. American Journal of Respiratory and Critical Care Medicine 2001;163(3):721-730. |
R825702 (Final) |
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Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW. A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. Journal of Immunology 2001;166(9):5792-5800. |
R825702 (Final) R825702C012 (Final) |
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Uhlson C, Harrison K, Allen CB, Ahmad S, White CW, Murphy RC. Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viability. Chemical Research in Toxicology 2002;15(7):896-906. |
R825702 (Final) R825702C014 (Final) |
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Wands JM, Roark CL, Aydintug MK, Jin N, Hahn Y-S, Cook L, Yin X, Dal Porto J, Lahn M, Hyde DM, Gelfand EW, Mason RJ, O'Brien RL, Born WK. Distribution and leukocyte contacts of γδ T cells in the lung. Journal of Leukocyte Biology 2005;78(5):1086-1096. |
R825702 (Final) |
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Wang J, Wang S, Manzer R, McConville G, Mason RJ. Ozone induces oxidative stress in rat alveolar type II and type I-like cells. Free Radical Biology & Medicine 2006;40(11):1914-1928. |
R825702 (Final) |
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Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen LD, Takeda K, Gelfand EW, Fisher JH, Zhang L, Malkinson AM, Mason RJ. Serum levels of surfactant protein D are increased in mice with lung tumors. Cancer Research 2003;63(18):5889-5894. |
R825702 (Final) R825702C001 (Final) |
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Zhao W, Hopke PK, Gelfand EW, Rabinovitch N. Use of an expanded receptor model for personal exposure analysis in schoolchildren with asthma. Atmospheric Environment 2007;41(19):4084-4096. |
R825702 (Final) |
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Supplemental Keywords:
Health, Scientific Discipline, Air, Health Risk Assessment, air toxics, Epidemiology, Risk Assessments, Disease & Cumulative Effects, Biochemistry, Atmospheric Sciences, Biology, health effects, air pollutants, acute lung injury, lung disease, lung epithelial cells, airway disease, susceptibility, human exposure, environmental toxicant, animal studies, genetic susceptibility, occupational disease, occupational exposureProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R825702C001 SP-A and SP-D in Environmental Lung Disease
R825702C003 Adaptation to Nitrogen Dioxide: Role of Altered Glycolytic Pathway Enzyme Expression and NF-κB-Dependent Cellular Defenses Against Apoptosis
R825702C005 Inhalation of Particulate Matter Alters the Allergic Airway Response to Inhaled Allergen
R825702C006 Particle-Induced Lung Inflammation and Extracellular EC-SOD
R825702C007 Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
R825702C008 The Role of Mitochondrial DNA Mutations in Oxidant-Mediated Lung Injury
R825702C009 Immunopathogenesis of Hypersensitivity Pneumonitis in the Mouse
R825702C010 Activation of Natural T Lymphocytes by Diesel Exhaust Particulates Leads to Their Production of Interleukin-4 and TH2 Lymphocyte Differentiation to Allergen
R825702C011 Latex Antigen Levels During Powdered and Powderless Glove Use
R825702C012 Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
R825702C013 Acute Exposure to Particulate Air Pollution in Childhood Asthma
R825702C014 Mechanisms of Ozone Toxicity to the Lung
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.