Grantee Research Project Results

2017 Progress Report: Metabolic, Microbiome and Toxicant-Related Interactions (MATRIX)

EPA Grant Number: R836153C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R836153
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Children’s Health, the Environment, Microbiome, and Metabolomics’ Center
Center Director: McCauley, Linda
Title: Metabolic, Microbiome and Toxicant-Related Interactions (MATRIX)
Investigators: Jones, Dean P. , Corwin, Elizabeth , Li, Shuzhao
Institution: Emory University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2020)
Project Period Covered by this Report: September 1, 2016 through August 31,2017
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

Aim 1: Identify maternal prenatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and preterm birth.

Aim 2: Identify maternal prenatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and infant neurodevelopment.

Aim 3: Identify infant postnatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and infant neurodevelopment.

Progress Summary:

Drs. Jones and Li have tested the planned metabolomics methodologies with legacy data, and are ready to apply those methodologies to the blood samples from Projects 1 and 2 as they are delivered to the laboratory. To this end, blood samples from the first 108 pregnant women enrolled in the P50 since January 2016 who have completed all data collections are scheduled for delivery to the Metabolomics Laboratory between May 1st and the 29th 2017.

Future Activities:

During the next reporting period, we will carry out the activities designated in the Timeline for Year 3. Specifically, together with our trained staff and following established protocols, we will continue receiving blood samples collected from enrolled pregnant women (Project 1) and their infants (Project 2), and perform metabolomics analyses on batched samples. We will also continue data coding and entry procedures and perform data analyses, including beginning integration of environmental exposures, microbiome, and metabolomics data as related to the outcome of preterm birth. We will continue to review progress with the investigative team and make adjustments if necessary. We will continue early dissemination efforts including abstract submissions and oral or poster (student) presentations, and participation in seminars and lectures related to Project 3 and C-CHEM2. We will actively pursue manuscript submissions and publications. We will also continue to engage with the Stakeholder Advisory Board to solicit their input into how we should disseminate findings to the African American community and clinical and public health care providers for this community.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Publications Views
Other subproject views:	All 10 publications	1 publications in selected types	All 1 journal articles
Other center views:	All 77 publications	31 publications in selected types	All 29 journal articles

Publications
Type	Citation	Sub Project	Document Sources
Journal Article	Li S, Dunlop AL, Jones DP, Corwin EJ. High-resolution metabolomics: review of the field and implications for nursing science and the study of preterm birth. Biological Research for Nursing 2016;18(1):12-22.	R836153C001 (2016) R836153C003 (2016) R836153C003 (2017)	Abstract from PubMed Abstract: SAGE Journals-Abstract Exit

Supplemental Keywords:

Metabolic, Metabolic pathway, metabolomics, environmental exposure, gut microbiome

Relevant Websites:

Center for Children's Health, the Environment, the Microbiome and Metabolomics Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R836153 Center for Children’s Health, the Environment, Microbiome, and Metabolomics’ Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836153C001 Characterizing Exposures and Outcomes in an Urban Birth Cohort (CHERUB)
R836153C002 Microbiome, Environment, and Neurodevelopmental Delay (MEND)
R836153C003 Metabolic, Microbiome and Toxicant-Related Interactions (MATRIX)

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.