Grantee Research Project Results
Organotypic Model of Human Kidney as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
EPA Grant Number: R835738C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R835738
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials
Center Director: Faustman, Elaine
Title: Organotypic Model of Human Kidney as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
Investigators: Kelly, Edward J.
Institution: University of Washington
EPA Project Officer: Aja, Hayley
Project Period: December 1, 2014 through November 30, 2018 (Extended to November 30, 2019)
RFA: Organotypic Culture Models for Predictive Toxicology Center (2013) RFA Text | Recipients Lists
Research Category: Chemical Safety for Sustainability
Objective:
The primary purpose of this project is to design, implement and test a tissue engineered human kidney microphysiological system. The system will be developed to fully evaluate uptake, metabolism and elimination of xenobiotics in a human tissue derived, in vitro 3-dimensional system that accurately reflects human physiology. The microphysiological system can be used to predict disposition kinetics of xenobiotics, and also assess the response to kidney injury inflicted by endogenous and exogenous toxicants, as well as from pathogens.
Approach:
Rationale:
Expected Results:
Publications and Presentations:
Publications have been submitted on this subproject: View all 64 publications for this subproject | View all 150 publications for this centerJournal Articles:
Journal Articles have been submitted on this subproject: View all 16 journal articles for this subproject | View all 49 journal articles for this centerProgress and Final Reports:
Main Center Abstract and Reports:
R835738 Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R835738C001 Airway Epithelium Organotypic Culture as a Platform forAdverseOutcomesPathway Assessment of Engineered Nanomaterials
R835738C002 Organotypic Model of Human Kidney as a Platform for Adverse Outcomes
Pathway Assessment of Engineered Nanomaterials
R835738C003 Organotypic Models of Mammalian Liver as a Platform for Adverse Outcomes
Pathway Assessment of Engineered Nanomaterials
R835738C004 Organotypic Model of Testis as a Platform for Adverse Outcomes Pathway
Assessment of Engineered Nanomaterials
R835738C005 Integrating Liver, Kidney and Testis Nanomaterial Toxicity using the
Adverse Outcome Pathway Approach
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
16 journal articles for this subproject
Main Center: R835738
150 publications for this center
49 journal articles for this center