Grantee Research Project Results
Final Report: Health Effects Institute (2005-2010)
EPA Grant Number: R832347Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2005-2010)
Investigators: Greenbaum, Daniel S.
Institution: Health Effects Institute
EPA Project Officer: Chung, Serena
Project Period: April 1, 2005 through March 31, 2010
Project Amount: $18,800,000
RFA: Health Effects Institute (2005) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
Targeted Strategic research in Four Key Areas:
• The Air Pollution Mixture: PM, Gases, Air Toxics
• Emerging Fuels and Technologies
• Assessing Health Impact of Air Quality Improvement (Accountability)
• An International Perspective
Summary/Accomplishments (Outputs/Outcomes):
HEI published 29 full Research Reports and 5 Special Reports and Communications on these priority topics. Among the Key Reports and Findings are:
The Air Pollution Mixture: Particulate Matter and Gases:
HEI completed over a dozen studies. These include research focused on:
§ Better characterizing exposure to PM and gases, including studies of outdoor, indoor, and personal exposure to PM and gases in several hundred individuals from a variety of potentially sensitive populations in seven U.S. and European cities;
§ Investigating potential mechanisms of effects on the heart and the role of different particle components and sizes;
§ Testing whether diesel or other particles can cause exacerbation of asthma and allergy, with real-world and controlled-human exposure studies as well as animal studies recently published or nearing completion; and;
§ Two new major analyses of long-term exposure to air pollution in U.S. (Krewski 2009) and European (Brunekreef 2009) population cohorts.
In 2010, HEI also completed a comprehensive review and synthesis of over 400 studies of exposure to and health effects from traffic-related air pollution (HEI Special Report 17).
The Air Pollution Mixture: Air Toxics
During the past five years, HEI has:
• Published Special Report 16, Mobile-Source Air Toxics: A Critical Review of the Literature on Exposure and Health Effects. The report, prepared by a special panel of experts appointed by HEI, focused on a list of 21 priority MSATs. The literature on seven compounds high on that list (acetaldehyde, acrolein, benzene, 1,3-butadiene, formaldehyde, naphthalene, and polycyclic organic matter) was critically reviewed, evaluated and summarized. The report was widely disseminated through briefings, workshops, the Web, on CD, and in print.
• HEI has also conducted a number of studies on 1,3-butadiene and acrolein, two of the priority chemicals identified by the MSAT panel. Especially important was the latest comprehensive study of mortality among 18,000 men who had worked at least one year in any of eight styrene-butadiene rubber plants between 1944 and 1998.
• In partnership with the Mickey Leland National Urban Air Toxics Research Center, HEI completed studies on the Relationships of Indoor, Outdoor, and Personal Air (RIOPA) (HEI Research Report 130, Parts I and II). The study documented concentrations of VOCs, carbonyls and PM2.5 in outdoor, indoor and personal air for approximately 100 subjects living in each of the three urban areas. The data generated in this study are available at http://riopa.aer.com. Also, under RFA 08-1, HEI has now initiated studies to analyze the RIOPA data in greater detail.
Other Programs
HEI also made substantial progress in these five years on:
• Emerging Fuels and Technologies (including publication of the Phase I report of the Advanced Collaborative Emissions Study (ACES) of the newest heavy duty diesel engines and controls
• Assessing the Health Impact of Air Quality Improvement (Accountability) – including publication of the first studies in East Germany and Atlanta
• An International Perspective – including completion of a revised comprehensive assessment of air pollution and health in Asia, and completion of a series of multi-city air pollution and mortality studies in Asia and Latin America.
References:
Publications/Presentations: As noted above, all HEI publications can be found at http://pubs.healtheffects.org/. In addition, for the 29 HEI Reports issued in these 5 years, there have been 92 publications in Peer-reviewed journals, and on average, each HEI report and its associated journal articles were cited 109 times in other research.
Journal Articles: 7 Displayed | Download in RIS Format
| Other center views: | All 7 publications | 7 publications in selected types | All 7 journal articles |
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Adams K, Greenbaum D, Shaikh R, van Erp A, Russell A. Particulate matter components, sources, and health:Systematic approaches to testing effects. Journal of the Air & Waste Management Association 2015;65(5):544-558. |
R832347 (Final) |
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Bzdek B, Zordan C, Pennington M, Luther GI, Johnston M. Quantitative Assessment of the Sulfuric Acid Contribution to New Particle Growth. ENVIRONMENTAL SCIENCE TECHNOLOGYH 2012;46(8):4365-4373. |
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Hartman J, Miller J, Boysen G. Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. TOXICOLOGY 2014;318:51-58. |
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Klems J, Pennington M, Zordan C, Johnston M. Ultrafine Particles Near a Roadway Intersection:Origin and Apportionment of Fast Changes in Concentration. ENVIRONMENTAL SCIENCE TECHNOLOGY 2010;44(20):7903-7907. |
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Klems J, Pennington M, Zordan C, McFadden L, Johnston M. Apportionment of Motor Vehicle Emissions from Fast Changes in Number Concentration and Chemical Composition of Ultrafine Particles Near a Roadway Intersection. ENVIRONMENTAL SCIENCE TECHNOLOGY 2011;45(13):5637-5643. |
R832347 (Final) |
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Klems J, Zordan C, Pennington M, Johnston M. Chemical Composition of Ambient Nanoparticles on a Particle-by-Particle Basis. ANALYTICAL CHEMISTRY 2012;84(5):2253-2259. |
R832347 (Final) |
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Zordan C, Pennington M, Johnston M. Elemental Composition of Nanoparticles with the Nano Aerosol Mass Spectrometer. ANALYTICAL CHEMISTRY 2010;82(19):8034-8038. |
R832347 (Final) |
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Supplemental Keywords:
air pollution, health effects, particulate matter, ozone, air toxics, diesel, fuels and technologies, accountabilityRelevant Websites:
Data Access sites:
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832347C135 Mechanisms of Particulate Matter Toxicity in Neonatal and Young Adult Rat Lungs
R832347C136 Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line
R832347C138 Health Effects of Real-World Exposure to Diesel Exhaust in Persons with Asthma
R832347C140 Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality
R832347C141 Air Pollution Effects on Ventricular Repolarization
R832347C143 Measurement and Modeling of Exposure to Selected Air Toxics for Health Effects Studies and Verification by Biomarkers
R832347C144 Genotoxicity of 1,3-Butadiene and Its Epoxy Intermediates
R832347C145 Effects of Concentrated Ambient Particles and Diesel Emissions on Rat Airways
R832347C147 Atmospheric Transformation of Diesel Emissions
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.