Grantee Research Project Results
2001 Progress Report: Cardiovascular Responses to Particulate Air Pollution
EPA Grant Number: R827994Title: Cardiovascular Responses to Particulate Air Pollution
Investigators: Liao, Duanping , Chinchilli, Vernon M. , Shy, Carl , Whitsel, Eric , Heiss, Gerardo , Xie, Sharon
Current Investigators: Liao, Duanping , Whitsel, Eric , Heiss, Gerardo , Lin, Hung-Mo , Duan, Yinkang
Institution: Pennsylvania State University
EPA Project Officer: Chung, Serena
Project Period: (Extended to April 30, 2004)
Project Period Covered by this Report: January 1, 2001 through January 1, 2002
Project Amount: $607,630
RFA: Airborne Particulate Matter Health Effects (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air , Human Health
Objective:
The objectives of this study are to: (1) abstract and create, from the USEPA Aerometric Information Retrieval System (AIRS), the average exposures to ambient criteria pollutants for the 15,792 individuals who participated in the Atherosclerosis Risk in Communities (ARIC) study, as 1-day, 2-day, 3-day, and/or 6-day averages prior to their randomly scheduled cohort clinical examinations (baseline in 1987-1989 and 4th exam in 1996-1998); (2) combine the air pollution data with the cardiovascular health data already collected by the ARIC investigators for examination of the independent relationships between exposure to criteria pollutants and cardiac autonomic control assessed by heart rate variability; cardiovascular reactivity assessed by postural changes of blood pressure and heart rate; inflammatory/hemostatic markers; and thepresence of arrhythmias assessed by 2-minute ECG rhythm strips. The investigators also will examine the relationships between criteria pollutants and validated cardiovascular diseases (CVD), including sudden cardiac death, myocardial infarction (MI), coronary heart disease (CHD), and stroke.
Progress Summary:
Specific Aims for Year 2 (January 15, 2001 - January 14, 2002)
- Continue analyses leading to publications and presentations.
- Prepare manuscripts for presentations and publications:
- Complete analysis of air pollution and cardiac autonomic control, and prepare presentations and publications.
- Complete analysis of air pollution and systemic inflammation, and prepare presentations and publications.
- Complete analysis of air pollution and cardiovascular reactivity, and prepare presentations and publications.
Progress/Accomplishments in Year 2:
- Completed statistical analyses for the research hypotheses and research questions relevant to the effects of each criteria pollutant.
- Manuscripts addressing the effects of individual criteria pollutants are in preparation.
- Completed analysis of PM10 and cardiac autonomic control.
- Completed analysis of gaseous pollutants and cardiac autonomic function.
- Completed analysis of PM10 and systemic inflammation.
- Completed analysis of gaseous pollutants and systemic inflammation.
- Completed analysis of criteria pollutants and cardiovascular reactivity.
- Started analysis investigating the relationship between criteria pollutants and arrhythmias and clinical CHD.
- Started analysis investigating the interrelationship between PM10 and gaseous pollutants on cardiovascular health.
Significance of the Work Completed in Year 2:
As listed in the abstracts and manuscripts section of this report, during the second year of this grant, the investigators have demonstrated that criteria pollutants (PM10, SO2, NO2, CO, and O3) are significantly associated with the following markers of cardiovascular disease vulnerability: (1) higher plasma hemostatic/inflammatory markers; (2) impaired cardiac autonomic control; and (3) impaired cardiovascular reactivity. More importantly, these associations are more pronounced among persons with a history of cardiovascular disease, indicating a more vulnerable subgroup of population. These results, if confirmed by other studies, indicate these three pathways as potential mechanisms linking air pollution to cardiovascular disease risk and mortality.
Future Activities:
The future activities for this research project will include completion of all analyses and manuscripts, submission of manuscripts to scientific journals and scientific meetings,close out and archival of study data, and delivery of study results to designated agency.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
| Other project views: | All 14 publications | 3 publications in selected types | All 3 journal articles |
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Xie SX, Liao D, Chinchilli VM. Measurement error reduction using weighted average method for repeated measurements from heterogeneous instruments. Environmetrics 2001;12(8):785-790. |
R827994 (2001) R827994 (Final) |
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Supplemental Keywords:
population-based study, public health, air pollution, ambient air, particulate matter, PM, PM10, ozone, heart disease, health effects, heart rate variability, inflammation, blood coagulation, epidemiology, RFA, Scientific Discipline, Health, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Atmospheric Sciences, Biology, ambient aerosol, copollutant exposures, particulates, air toxics, cardiopulmonary responses, human health effects, cardiovascular vulnerability, heart rate variability, air pollution, chronic health effects, particulate exposure, ethnicity, Acute health effects, blood pressure, PM, cardiotoxicity, myocardium infarction, cardiac arrhythmiasProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.