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Grantee Research Project Results

Publications submitted after final report Details for Grant Number R835166

Carolina Center for Computational Toxicology: Assays, models and tools for NextGen safety assessments

RFA: Developing High-Throughput Assays for Predictive Modeling of Reproductive and Developmental Toxicity Modulated Through the Endocrine System or Pertinent Pathways in Humans and Species Relevant to Ecological Risk Assessment (2011)

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Journal Article (9)
Presentation (5)
Reference Type Citation Progress Report Year (Date Added to Report) Document Sources
Journal Article Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environment International 2015;85:147-155. R835166 (2015) (04/23/25)
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Journal Article Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives 2015;123(5):458-466. R835166 (2015) (04/23/25)
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Journal Article Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schuurmann G, White A, Burton J, Lostia AM, Munn S, Worth A. Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making. Environmental Health Perspectives 2015;123(12):1232-1240. R835166 (2015) (04/23/25)
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Journal Article Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J. Prediction of human population responses to toxic compounds by a collaborative competition. Nature Biotechnology 2015;33(9):933-940. R835166 (2015) (04/23/25)
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Journal Article Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. R835166 (Final) (04/30/19)
R835802 (2018) (07/16/19)
R835802C001 (2018) (07/22/19)
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Journal Article Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling:A case study with the mycotoxin deoxynivalenol. ENVIRONMENT INTERNATIONAL 2023;182(108326). R835166 (Final) (01/26/24)
R835802 (Final) (01/26/24)
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Journal Article Lu E, Ford L, Chen Z, Burnett S, Rusyn I, Chiu W. Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2024;148(105596) R835166 (Final) (06/17/24)
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Journal Article Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS. CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. Environmental Health Perspectives 2016;124(7):1023-1033. R835166 (2015) (04/23/25)
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Journal Article Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW. Toxicokinetic triage for environmental chemicals. Toxicological Sciences 2015;147(1):55-67. R835166 (2015) (04/23/25)
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Presentation Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C. The 1000 genomes toxicity screening project:utilizing the power of human genome variation for population scale in vitro testing. Presented at the Society of Toxicology 52nd Annual Meeting & ToxExpo™, San Antonio, TX, March 10-14, 2013. R835166 (Final) (04/30/19)
not available
Presentation Grimm FA, Iwata Y, Sirenko O, Crittenden C, Roy T, Boogaard P, Ketelslegers H, Rohde A, Rusyn I. Toxicological categorization of petroleum substances through high-content screening of induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes. Presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. R835166 (2015) (04/23/25)
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Presentation Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835166 (2015) (04/23/25)
R835802 (2018) (07/16/19)
not available
Presentation Rusyn I. Categorization of UVCBs using chemical-biological read across. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835166 (Final) (04/30/19)
R835802 (2018) (07/16/19)
not available
Presentation Rusyn I. Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835166 (Final) (04/30/19)
R835802 (2018) (07/16/19)
not available

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