IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)
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1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. Additional information regarding 1,4-dioxane toxicity resulting from exposure via inhalation has now been incorporated into the 2010 assessment without changing the oral toxicity conclusions of the previous assessment.
|Aug 2010||EPA released the final assessmentof 1,4-dioxane on the IRIS Web site.|
|May 2011||EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.|
|Sep 2011||EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.|
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