IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)
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1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. Additional information regarding 1,4-dioxane toxicity resulting from exposure via inhalation has now been incorporated into the 2010 assessment without changing the oral toxicity conclusions of the previous assessment.
|Aug 1988||EPA released the assessment for 1,4-Dioxane.|
|Oct 2003||The IRIS reassessment of 1,4-dioxane was initiated.|
|May 2009||EPA released an external review draft for public review and comment.|
|Sep 2009||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.|
|Aug 2010||EPA released the final assessment of 1,4-dioxane on the IRIS Web site.|
|May 2011||EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.|
|Sep 2011||EPA released the external review draft (with inhaltaion update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.|
|Sep 2011||EPA extended the close of the public comment period to November 15, 2011. [Federal Register Notice Sep16, 2011]|
|Feb 2012||EPA announced that an independent panel of experts will meet in Morrisville, NC on March 19, 2012 to discuss the draft report. [Federal Register Notice Feb 13, 2012]|
|May 2012||EPA released the comments from the public comment period and external review workshop.|
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