Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Ammonium Picrate

CASRN 131-74-8

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/23/2020
System RfD (mg/kg-day) Basis PoD UF Confidence
Hematologic 2 x 10-3 Increased MetHb and spleen-erythroid cell hyperplasia NOAEL(HED) : 0.643 mg/kg-day 300
Species Studied: Rat/M
Principal Study: Reddy et al. (2001); Reddy et al. (1997)


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/23/2020
System RfD (mg/kg-day) Basis PoD UF Confidence
Immune 6 x 10-3 Increased absolute spleen weight BMDL1SD(HED) : 1.8 mg/kg-day 300
Species Studied: Rat/M
Principal Study: Takahashi et al. 2004


Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/23/2020
Not determined

Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/23/2020
Not determined

Cancer Assessment

Weight of Evidence for CancerLast Updated: 09/23/2020
IN - Inadequate information to assess carcinogenic potential

Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/23/2020
Not determined

Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 09/23/2020
Not determined

Provisional Peer-Reviewed Toxicity Values (PPRTVs)