Provisional Peer-Reviewed Toxicity Values (PPRTVs)

1,2-Dichloroethane

CASRN 107-06-2

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/01/2010
See attachment to the assessment's appendix for quantitative screening values.

Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/01/2010
System RfD (mg/kg-day) Basis PoD UF Confidence
Urinary 2 x 10-2 Greater than 10 percent increase in relative kidney weight LOAEL : 58 mg/kg-day 3000 Medium
Species Studied: Rat
Duration: 13 weeks
Principal Study: NTP 1991


Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/01/2010
System RfC (mg/m3) Basis PoD UF Confidence
Nervous 7 x 10-3 Neurobehavioral impairment LOAEL(HEC) : 22 mg/m3 3000 Low
Species Studied: Human
Duration: Occupational
Principal Study: Kozik 1957


Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/01/2010
System RfC (mg/m3) Basis PoD UF Confidence
Nervous 7 x 10-2 Neurobehavioral impairment LOAEL(HEC) : 22 mg/m3 300 Low
Species Studied: Human
Duration: Occupational
Principal Study: Kozik 1957

Cancer Assessment

Weight of Evidence for CancerLast Updated: 10/01/2010
Please see IRIS.

Provisional Peer-Reviewed Toxicity Values (PPRTVs)