1,2-Dichloroethane

CASRN 107-06-2

  • IRIS Summary (PDF) (11 pp, 108 K)
  • Status: 1,2-Dichloroethane is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (11 pp, 108 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (11 pp, 108 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (11 pp, 108 K) last updated: 03/31/1987

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on the induction of several tumor types in rats and mice treated by gavage and lung papillomas in mice after topical application
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 108 K)

Oral Slope Factor: 9.1 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 2.6 x10 -6 per µg/L
Extrapolation Method: Linearized multistage procedure with time-to-death analysis, extra risk
Tumor site(s): Other
Tumor type(s): Hemangiosarcomas (NCI, 1978)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (11 pp, 108 K)

Inhalation Unit Risk: 2.6 x10 -5 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Other
Tumor type(s): Hemangiosarcomas (NCI, 1978)


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