US EPA

In April 2023, the IRIS Program released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for public comment and external peer review. The IRIS assessment of PFDA will undergo an independent external scientific peer review managed by ERG, a contractor to EPA. Additional information about the peer review meeting is listed with the downloads below and located on the external peer review meeting site.

U.S. EPA. IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Public Comment and External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/056a, 2023.

Perfluorodecanoic Acid (PFDA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. Concerns about PFDA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFDA has been used in stain and grease-proof coatings on food packaging, furniture, upholstery, and carpet. PFDA has also been detected in nano- and impregnation-sprays, outdoor textiles, carpet, gloves, paper-based food contact materials, ski wax, and leather. Exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFDA-containing products.

Date	Description
01-Nov 2019	EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]
02-Jul 2020	EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.
03-Mar 2022	EPA sent an interagency science consultation PFDA draft for review and comment.
04-Apr 2023	EPA released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for a 60-day public comment period and external peer review. EPA also released the interagency science consultation comments from reviewers. [Federal Register Notice: April 10, 2023 ]

The toxicological review of PFDA and related salts was released for a 60-day public comment period and external peer review. Following the external peer review meeting, the assessment will be revised, taking into consideration all public and external peer review comments received.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please contact Dahnish Shams (shams.dahnish@epa.gov) AND the IRIS Hotline at hotline.iris@epa.gov. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Salts (Public Comment and External Review Draft) (PDF)  (420 pp, 12 MB, about PDF)
• IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Public Comment and External Review Draft) Supplemental Information (PDF)  (147 pp, 4 MB, about PDF)
• Draft External Peer Review Charge Questions for the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (PDF)  (8 pp, 241 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

• Systematic Review Protocol for the PFAS IRIS Assessments (2021)
• Systematic Review Protocol for the Perfluorodecanoic Acid (PFDA) IRIS Assessments (Preliminary Assessment Materials)
• Toxicological Review of Perfluorodecanoic Acid (PFDA) (Interagency Science Consultation Draft, 2022)
• External Peer Review Activities for PFDA Integrated Risk Information System (IRIS) Assessment (2023)

• Primary Literature Search References Sorted By Author (PFDA)

• FR Notice: Apr 10, 2023

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2019-0287