Toxicological Review of Perfluorodecanoic Acid (Pfda) (Interagency Science Consultation Draft, 2022)
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Abstract
Perfluorodecanoic Acid (PFDA, CASRN 375-22 -4) is a member of the group per and polyfluoroalkyl substances (PFAS). Concerns about PFDA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFASs are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. PFDA is a breakdown product of other PFASs that are used in stain-resistant fabrics, paper food packaging, and carpets; it was also used for manufacturing photographic film, and it is used as a substitute for longer chain perfluorocarboxylic acids (PFCAs) in consumer products. PFDA has been found to accumulate in agricultural crops and it has been detected in household dust, soils, food products, and surface, ground, and drinking water. As such, exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFDA-containing products.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Nov 2019 | EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
Mar 2022 | EPA sent an interagency science consultation PFDA draft for review and comment. |
Apr 2023 | EPA released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for a 60-day public comment period and external peer review. EPA also released the interagency science consultation comments from reviewers. [Federal Register Notice: April 10, 2023 ] |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- 1. ATSDR PFDA IASC Comments March 2022 (PDF) (7 pp, 237 KB, about PDF)
- 2. DoD PFDA IASC Comments Mar 2022 (PDF) (6 pp, 99 KB, about PDF)
- 3. EOP OMB PFDA IASC Comments Mar 2022 (PDF) (4 pp, 165 KB, about PDF)
- 4. NIEHS PFDA IASC Comments Mar 2022 (PDF) (8 pp, 265 KB, about PDF)
- 5. NIOSH PFDA IASC Comments Mar 2022 (PDF) (3 pp, 159 KB, about PDF)
Related Link(s)
- Systematic Review Protocol for the PFAS IRIS Assessments (2021)
- Systematic Review Protocol for the Perfluorodecanoic Acid (Pfda) IRIS Assessments (Preliminary Assessment Materials)
- IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Public Comment and External Review Draft)