Perfluorobutanoic Acid (PFBA)
IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft, 2021)
U.S. EPA. IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft, 2021). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-20/424, 2021.
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Perfluorobutanoic Acid (PFBA, CASRN 375-224) and its related salt (ammonium perfluorobutanoic acid [NH4+PFBA], CASRN 10495-86-0) are members of the group of per and polyfluoroalkyl substances (PFAS). Concerns about PFBA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water.
PFBA is a breakdown product of other PFAS that are used in stain-resistant fabrics, paper food packaging, and carpets; it is also used for manufacturing photographic film, and it is used as a substitute for longer chain perfluoroalkyl carboxylic acids (PFCAs) in consumer products. PFBA has been found to accumulate in agricultural crops and has been detected in household dust, soils, food products, and surface, ground, and drinking water.
As such, exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFBA-containing products.
|Nov 2019||EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]|
|Jul 2020||EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.|
|Aug 2020||EPA sent an interagency science consultation PFBA draft for review and comment.|
|Aug 2021||EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021]|
The Perfluorobutanoic Acid (PFBA) IRIS assessment was released for a 60-day public comment period. Following the external peer review meeting, the assessment will be revised taking into consideration all public and external peer review comments received.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2020-0675