IRIS

Perfluorobutanoic Acid (PFBA)

CASRN 375-22-4

IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft, 2021)

Notice

EPA announced the release of the IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft) for a 60-day public comment and review period.

Overview

The IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid was released for public comment and external peer review in August 2021. The IRIS assessment of PFBA will undergo an independent external scientific peer review managed by Eastern Research Group, Inc. (ERG), a contractor to EPA. Additional information about the peer review will be posted on the IRIS website. Additionally, the same peer review panel will conduct all five (5) PFAS IRIS assessments.

Citation

U.S. EPA. IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft, 2021). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-20/424, 2021.

Contact

J. Allen Davis,  Ph:  919-541-3789,  Email: davis.allen@epa.gov

Michelem Taylor,  Email: taylor.michelem@epa.gov

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Background

Perfluorobutanoic Acid (PFBA, CASRN 375-224) and its related salt (ammonium perfluorobutanoic acid [NH4+PFBA], CASRN 10495-86-0) are members of the group of per and polyfluoroalkyl substances (PFAS). Concerns about PFBA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water.

PFBA is a breakdown product of other PFAS that are used in stain-resistant fabrics, paper food packaging, and carpets; it is also used for manufacturing photographic film, and it is used as a substitute for longer chain perfluoroalkyl carboxylic acids (PFCAs) in consumer products. PFBA has been found to accumulate in agricultural crops and has been detected in household dust, soils, food products, and surface, ground, and drinking water.

As such, exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFBA-containing products.

History/Chronology

Date Description
Nov 2019EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]
Jul 2020EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.
Aug 2020EPA sent an interagency science consultation PFBA draft for review and comment.
Aug 2021EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021]

Status

The Perfluorobutanoic Acid (PFBA) IRIS assessment was released for a 60-day public comment period. Following the external peer review meeting, the assessment will be revised taking into consideration all public and external peer review comments received.


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