IRIS

Ammonia

CASRN 7664-41-7

IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral (Scoping and Problem Formulation Materials)

Notice

EPA announced the availability of the IRIS Assessment Plan for Ammonia and Ammonium Salts: Noncancer Assessment for Oral Exposure (Scoping and Problem Formulation Materials) for a 30-day public comment period as announced in an April 16, 2018 Federal Register Notice.

Overview

In April 2018, EPA released the draft IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.

Citation

U.S. EPA. IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/041, 2018.

Contact

Vincent J. Cogliano,  Ph:  202-564-4313,  Email: cogliano.vincent@epa.gov

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Background

Ammonia occurs naturally in air, soil, and water. Ammonia is also produced by humans and other animals as part of normal biological processes. Ammonia is used as an agricultural fertilizer and in many cleaning products. Exposure to ammonia occurs primarily through breathing air containing ammonia gas, and may also occur via diet, drinking water, or direct skin contact.

History/Chronology

Date Description
Apr 2018EPA released the IRIS Assessment Plan for Ammonia and Ammonium Salts (noncancer oral exposure) for a 30-day public comment period.[Federal Register Notice Apr 16, 2018]
Sep 2016EPA released the final IRIS Toxicological Review of Ammonia (noncancer Inhalation) to the IRIS database.

Status

The IRIS Program will use the IAP to inform the subsequent development of a chemical-specific systematic review protocol.


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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2018-0132

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