IRIS Toxicological Review of Ammonia (Revised External Review Draft)
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Report Information: The Toxicological Review of Ammonia was originally released for a 60-day public comment period on June 8, 2012. [Federal Register Notice Jun 8, 2012] EPA revised the toxicological review in response to the public comments received. EPA has released the revised external review draft ammonia assessment and the SAB CAAC is conducting a peer review of the scientific basis supporting the assessment that will appear in the Integrated Risk Information System (IRIS) database. Information regarding the peer review can be found at the SAB review of ammonia website.
About 80% of commercially produced ammonia is used in agricultural fertilizers. Ammonia is also used as a corrosion inhibitor, in water purification, as a household cleaner, as an antimicrobial agent in food products, as a refrigerant, as a stabilizer in the rubber industry, as a source of hydrogen in the hydrogenation of fats and oils, and as a chemical intermediate in the production of pharmaceuticals, explosives, and other chemicals. Ammonia is also used to reduce nitrogen oxide emissions from combustion sources such as industrial and municipal boilers, power generators, and diesel engines. Ammonia is a component of the global nitrogen cycle and is essential to many biologic processes.
Information on the peer review can be found at the SAB Ammonia website. Following external peer review, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA, and other federal agencies and the Executive Office of the President. After completing this review it will be posted to the IRIS database.
|May 1991||The RfC for ammonia was posted to the IRIS database.|
|Mar 2012||EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Ammonia.|
|Jun 2012||EPA released the external review draft of the ammonia assessment for public review and comment. Additionally, the interagency science consultation draft, comments from reviewers, and EPA's responses to selected major interagency comments were also released. [Federal Register Notice Jun 8, 2012]|
|Aug 2013||EPA's Science Advisory Board (SAB) announced a request for nominations for experts to augment the SAB Chemical Assessment Advisory Committee (CAAC) for the review of the EPA's draft IRIS assessment for ammonia [Federal Register Notice Aug 28, 2013] (3pp., 210Kb, about PDF), and made available the revised external review draft assessment and draft charge to peer reviewers.|
|Jan 2014||EPA's SAB announced a 3-day public peer review meeting for the draft IRIS Toxicological Review of Ammonia for Feb 18-20, 2014. [Federal Register Notice Jan 31, 2014]|
|Feb 2014||To provide the public with additional time to prepare, EPA SAB staff office is rescheduling the February 18-20 meeting of the SAB Chemical Assessment Advisory Committee (CAAC). The EPA SAB staff office will announce a new date in the near future.|
|Mar 2014||EPA's SAB announced two meetings for the SAB CAAC-Ammonia panel for the review of the draft IRIS assessment of ammonia. A public teleconference is scheduled for June 2, 2014. A face-to face panel meeting is scheduled for July 14-16, 2014 in Arlington,VA. [Federal Register Notice Mar 25, 2014]|
|Mar 2014||EPA updated the peer review charge to include a question regarding EPA's assessment revisions and response to public comments.|
|Aprl 2014||EPA's SAB announced a correction in the Federal Register regarding the date of the CAAC-Ammonia teleconference, the correct date is June 2, 2014. [SAB FR Notice for April 9, 2014]|
|Jul 2014||EPA updated the peer review charge by adding annotations referring the reader to relevant sections of the draft assessment in order to facilitate review.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.