IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft)
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U.S. EPA. IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/011D, 2011.
The draft Toxicological Review of Trichloroethylene (TCE) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to TCE. TCE is a chlorinated solvent that has been widely used as a metal degreaser, as a chemical intermediate and extractant, and as a component of some consumer products. TCE is designated as a Hazardous Air Pollutant, is a common groundwater contaminant, and has been found at more than 1,500 hazardous waste sites. TCE enters the atmosphere from vapor degreasing operations or volatilization from contaminated soils, surface waters via direct discharges, and groundwater through leaching from disposal operations and hazardous waste sites. In addition, TCE can be released to indoor air from the use of TCE-containing consumer products, volatilization from water supplies, and vapor intrusion through walls and floors from contaminated soil and groundwater.
|Aug 2001||EPA released an External review draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization for public review and comment.|
|Dec 2002||EPA's Science Advisory Board released an independent peer review report Review of Draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization: An EPA Science Advisory Board Report (PDF, 83 pp, 376 KB, about PDF).|
|Feb 2004||EPA hosted a Symposium on New Scientific Research Related to the Health Effects of Trichloroethylene held in Washington, DC.|
|Sep 2004||The National Academy of Science (NAS) initiated the project “Assessing the Human Health Risks of Trichloroethylene : Key Scientific Issues” under sponsorship of EPA and other federal agencies.|
|Feb 2005||EPA submitted four TCE issue papers on key scientific issues to the NAS.|
|July 2006||The National Academy of Science (NAS) released the report Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues Consultation.|
|Sep 2009||EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Trichloroethylene.|
|Oct 2009||EPA Science Advisory Board (SAB) releases Federal Register Notice requesting nominations of experts for the SAB TCE Review Panel.|
|Nov 2009||EPA releases the External Review draft for public comment and review.|
|Dec 2009||EPA announced a listening session to be held on January 26, 2010 in the Federal Register Dec 21, 2009, more details can be found in the earlier Decemeber 11, 2009 Federal Register.|
|Jan 2010||SAB released the names and biosketches of the "Short List Candidates" for the upcoming TCE Review Panel.|
|Mar 2010||SAB hosted two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (4/20/10) and a face-to-face meeting (5/10-12) to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Mar 31, 2010]|
|Jun/Jul 2010||EPA's SAB announced two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (6/24/10) and another teleconference (9/13/10) to discuss the review of EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Jun 2, 2010, Federal Register Jul 27, 2010]|
|Dec 2010||SAB hosted a public meeting of the SAB Trichloroethylene (TCE) Review Panel: by teleconference held on 12/15/10 to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Nov 24, 2010]|
|Jan 2011||SAB released the final report, Review of EPA's Draft Assessment entitled "Toxicological Review of Trichloroethylene". (PDF, 68 pp., 407, 129 bytes), EPA-SAB-11-002.|
|Jul 2011||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of TCE.|
|Sep 2011||EPA releases the final toxicological review and IRIS Summary for TCE and the interagency science discussion draft with interagency comments.|
This assessment has been loaded into the IRIS Web site and Database.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.