IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)
Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. These files are no longer maintained by the Agency and may be outdated. For current EPA information, go to www.epa.gov. It is EPA's policy to support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact EPA's Reasonable Accommodations or submit a request using the Contact Us form.
The draft Toxicological Review of Trichloroethylene (TCE) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to TCE. TCE is a chlorinated solvent that has been widely used as a metal degreaser, as a chemical intermediate and extractant, and as a component of some consumer products. TCE is designated as a Hazardous Air Pollutant, is a common groundwater contaminant, and has been found at more than 1,500 hazardous waste sites. TCE enters the atmosphere from vapor degreasing operations or volatilization from contaminated soils, surface waters via direct discharges, and groundwater through leaching from disposal operations and hazardous waste sites. In addition, TCE can be released to indoor air from the use of TCE-containing consumer products, volatilization from water supplies, and vapor intrusion through walls and floors from contaminated soil and groundwater.
The final Trichloroethylene IRIS document is expected to be publicly available during the 4th quarter of FY 2011.
|Aug 2001||EPA released an external review draft, Trichloroethylene Health Risk Assessment: Synthesis and Characterization for public review and comment.|
|Dec 2002||EPA's Science Advisory Board (SAB) released an independent peer review report Review of Draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization: An EPA Science Advisory Board Report (PDF, 83 pp, 376 KB, about PDF).|
|Feb 2004||EPA hosts a Symposium on New Scientific Research Related to the Health Effects of Trichloroethylene held in Washington, DC.|
|Sep 2004||The National Academy of Science (NAS) initiated the project “Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues” under sponsorship of EPA and other federal agencies.|
|Feb 2005||EPA submitted four TCE issue papers on key scientific issues to the NAS.|
|July 2006||NAS released the report Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues Consultation.|
|Nov 2009||EPA released the draft Toxicological Review of Trichloroethylene (TCE) for public review and comment. Additionally, as per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCE draft report have also been released. [Federal Register Nov 3, 2009]|
|Dec 2009||EPA announced a listening session to be held on January 26, 2010 in the Federal Register Dec 21, 2009, more details can be found in Federal Register Dec 11, 2009.|
|Jan 2010||SAB released the names and biosketches of the "Short List Candidates" for the upcoming TCE Review Panel.|
|Mar 2010||SAB hosted two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (4/20/10) and a face-to-face meeting (5/10-12) to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Mar 31, 2010]|
|Jun/Jul 2010||EPA's SAB announced two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (6/24/10) and another teleconference (9/13/10) to discuss the review of EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Jun 2, 2010, Federal Register Jul 27, 2010]|
|Dec 2010||SAB hosted a public meeting of the SAB Trichloroethylene (TCE) Review Panel: by two teleconferences held on 12/15-16/10 to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Nov 24, 2010]|
|Jan 2011||SAB released the final report, Review of EPA's Draft Assessment entitled "Toxicological Review of Trichloroethylene. (PDF, 68 pp., 407,129 bytes), EPA-SAB-11-002|
Instructions for accessing supplementary files to Appendices A, F, and G.
(1) Download "Appendix_linked_files.zip" file.
(2) "Extract" files using Microsoft Windows or equivalent decompression software, creating a folder named "Appendix.linked.files"
(3) Move the folder "Appendix.linked.files" to the same directory where the PDF file for Appendix A, F, or G is located.
(4) Open the PDF file for Appendix A, F, or G using Adobe Acrobat Reader. To open the supplementary files, click on the appropriate links.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (1109 pp, 7 MB, about PDF)
- (1221 pp, 9 MB, about PDF)
- (5 pp, 153 KB, about PDF)
- (44 pp, 275 KB, about PDF)
- (2 pp, 132 KB, about PDF)
- (25 pp, 441 KB, about PDF)
- (139 pp, 1 MB, about PDF)
- (330 pp, 2 MB, about PDF)
- (291 pp, 3 MB, about PDF)
- (153 pp, 2 MB, about PDF)
- (42 pp, 400 KB, about PDF)
- (83 pp, 604 KB, about PDF)
- (116 pp, 1 MB, about PDF)
- (365 pp, 2 MB, about PDF)
- (68 pp, 664 KB, about PDF)
- (133 pp, 999 KB, about PDF)
- (445 pp, 2 MB, about PDF)
- (45 pp, 686 KB, about PDF)
- (43 pp, 1 MB, about PDF)
- (6 pp, 251 KB, about PDF)
- (0 KB, about ZIP)
- (68 pp, 407 KB, about PDF)
- (NA pp, 351 KB, about PDF)