IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)
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U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/003C, 2011.
1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. Additional information regarding 1,4-dioxane toxicity resulting from exposure via inhalation has now been incorporated into the 2010 assessment without changing the oral toxicity conclusions of the previous assessment.
|Aug 2010||EPA released the final assessment of 1,4-dioxane on the IRIS Web site.|
|May 2011||EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.|
|Sep 2011||EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.|
Following external peer review the assessment will be revised taking into consideration external peer review and public comments. The revised assessment will undergo a final EPA internal review and review by other federal agencies and White House offices, then the final assessment will be posted to the IRIS database.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.