Pentachlorophenol

CASRN 87-86-5

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 261 K) last updated: 09/30/2010

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
5 x10-3 Hepatic Hepatotoxicity LOAEL : 1.5
mg/kg-day
300 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 261 K) last updated: 09/30/2010
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (27 pp, 261 K) last updated: 09/30/2010

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), PCP is "likely to be carcinogenic to humans."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 261 K)

Oral Slope Factor: 4 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 1.1 x10 -5 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic, Endocrine
Tumor type(s): Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas (NTP, 1989)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 261 K)

Not Assessed under the IRIS Program.

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