Nitrobenzene

CASRN 98-95-3

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (30 pp, 257 K) last updated: 02/06/2009

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
2 x10-3 Hematologic Increased methemoglobin levels BMDL (1SD): 1.8
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (30 pp, 257 K) last updated: 02/06/2009

RfC (mg/m3) System Basis PoD Composite UF Confidence
9 x10-3 Nervous, Respiratory Bronchiolization of the alveoli and olfactory degeneration BMCL10 (HEC): 0.26
mg/m3
30 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (30 pp, 257 K) last updated: 02/06/2009

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans (Combined route) Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), nitrobenzene is classified as "likely to be carcinogenic to humans" by any route of exposure.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (30 pp, 257 K)

Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (30 pp, 257 K)

Inhalation Unit Risk: 4 x10 -5 per µg/m3
Extrapolation Method: Multistage model with linear extrapolation from the POD (LEC10).
Tumor site(s): Hepatic, Urinary, Endocrine
Tumor type(s): Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas (CIIT (1993))


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