CASRN 98-95-3

IRIS Toxicological Review of Nitrobenzene (External Review Draft)

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EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessments of nitrobenzene, that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

Nitrobenzene is used extensively in chemical manufacturing, especially in the synthesis of other industrial chemicals and intermediates. Most important among these is aniline. A re-assessment of the potential health effects of nitrobenzene has been undertaken. The draft assessment will present reference values for the noncancer effects (RfD and RfC) and a cancer assessment (IUR).


U.S. EPA. IRIS Toxicological Review of Nitrobenzene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-07/001.


Ghazi Dannan,  Ph:  703-308-9549,  Email:

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IRIS is a database that contains information regarding potential adverse human health effects that may result from chronic (or lifetime) exposure to specific chemical substances found in the environment. The database (available in the Internet at http://ww/ contains qualitative and quantitative helath effects information for more than 540 chemical substances that may be used to support the first two steps of a risk assessment process. When supported by available data, the database provides oral reference doses (RfDs) and inhalation reference concentrations (RfCs) for chronic health effects, and oral slope factors and inhalation unit risks for carcinogenic effects.

Combined with specific exposure information, government and private entities can use IRIS to help characterize public health risks of chemical substances in a site-specific situation and thereby support risk management decision designed to protect public health.


Date Description
Mar 2007EPA released the external review draft for public review and comment.
May 2007EPA hosted an independent peer review panel workshop to discuss the draft report.
Feb 2009EPA released the final Toxicological Review of Nitrobenzene: in support of the Integrated Risk Information System (IRIS).


Following the External Peer Review, the final assessment will be published on the IRIS database.

Additional Information

Included for public review are the draft Toxicological Review for Nitrobenzene, a draft Appendix to the Toxicological Review, and a charge to external peer reviewers for EPA's health assessment of nitrobenzene. Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2007-0241 (for the docket ID) to comment on this report.

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