IRIS

Perfluorohexanoic Acid (PFHxA)

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Developmental	5 x 10^-4 (Chronic)	Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats	BMD (HED): 4.8 x 10^-2 mg/kg-day	100	Medium
Developmental	5 x 10^-4 (Subchronic)	Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats	BMD (HED): 4.8 x 10^-2 mg/kg-day	100	Medium

Note: BMDL 5%RD.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
Information reviewed but value not estimated.

Note: NA

Weight of Evidence for Cancer (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
Information reviewed but value not estimated.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

System	RfD (mg/kg-day)	Basis	POD	UF	Confidence
Developmental	5 x 10^-4	Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats	BMD (HED): 4.8 x 10^-2 mg/kg-day	100	Medium
Hepatic	4 x 10^-4	Increased hepatocellular hypertrophy in adult male Crl:CD Sprague‑Dawley rats	BMD (HED): 1.1 x 10^-1 mg/kg-day	300	Medium
Hematologic	5 x 10^-3	Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats	BMD (HED): 5.2 x 10^-1 mg/kg-day	100	Medium