IRIS

Perfluorodecanoic Acid (PFDA)

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Immune	2 x 10^-9 (Chronic)	Decreased serum antibody concentrations for tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr.	BMDL (HED): 6.04 x 10^-8 mg/kg-day	30	Medium
Immune	2 x 10^-9 (Subchronic)	Decreased serum antibody concentrations for both tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr	BMDL (HED): 6.04 x 10^-8 mg/kg-day	30	Medium

Note: BMDL of 1/2 SD

Reference Concentration for Inhalation Exposure (RfC) (PDF) (7 pp, 403 K) Last Updated: 07/15/2024
Not assessed under the IRIS Program.

Weight of Evidence for Cancer (PDF) (7 pp, 403 K) Last Updated: 07/15/2024
Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

System	RfD (mg/kg-day)	Basis	POD	UF	Confidence
Immune	2 x 10^-9	Decreased serum antibody concentrations for tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr.	BMDL (HED): 6.04 x 10^-8 mg/kg-day	30	Medium
Developmental	2 x 10^-9	Decreased birth weight in male and female children.	BMDL (HED): 5.44 x 10^-8 mg/kg-day	30	Medium-Low