Hydrogen Cyanide and Cyanide Salts

CASRN Various

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 243 K) last updated: 09/28/2010

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
6 x10-4 Reproductive Decreased cauda epididymis weight in male F344/N rats BMDL (1SD): 1.9
mg/kg-day
3000 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 243 K) last updated: 09/28/2010

RfC (mg/m3) System Basis PoD Composite UF Confidence
8 x10-4 Endocrine Thyroid enlargement and altered iodide uptake LOAEL (ADJ): 2.5
mg/m3
3000 Low/Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (27 pp, 243 K) last updated: 09/28/2010

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, there is "inadequate information to assess the carcinogenic potential" of cyanide.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

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