IRIS

Cyanide, free

CASRN 57-12-5

The assessment summary for cyanide, free is based on the Toxicological Review for Hydrogen Cyanide and Cyanide Salts (see related topics). The RfD value for cyanide, free is presented in Section I.A.3 of the IRIS Summary as well as Section 5.1.3 of the toxicological review.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 243 K) last updated: 09/28/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
6.3 x 10-4 Decreased cauda epididymis weight in male #344/N rats. The RfD for cyanide, free is presented in section 1.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. 3000 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 243 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (27 pp, 243 K) last updated: 03/01/1991

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Pertinent data regarding carcinogenicity have not been located in the available literature.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

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