1,1,1-Trichloroethane

CASRN 71-55-6

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (55 pp, 386 K) last updated: 09/28/2007

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
2
(Chronic)
Other Reduced body weight BMDL10 : 2155
mg/kg-day
1000 Low/Medium
7
(Subchronic)
Other Reduced body weight BMDL10 : 2155
mg/kg-day
300 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (55 pp, 386 K) last updated: 09/28/2007

RfC (mg/m3) System Basis PoD Composite UF Confidence
5
(Chronic)
Hepatic Liver histopathologic changes NOAEL (HEC): 1553
mg/m3
100 Medium
5
(Subchronic)
Hepatic Liver histopathologic changes NOAEL (HEC): 1553
mg/m3
100 Medium
5
(Short-term)
Hepatic Performance on neurobehavioral tests LOAEL : 526
mg/m3
100 Medium
6
(Acute: 24 hours)
Hepatic Performance on neurobehavioral tests NOAEL : 950
mg/m3
100 Medium
7
(Acute: 8 hours)
Hepatic Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium
7
(Acute: 4 hours)
Hepatic Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium
9
(Acute: 1 hour)
Hepatic Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (55 pp, 386 K) last updated: 09/28/2007

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 1,1,1-trichloroethane provides "inadequate information to assess carcinogenic potential."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (55 pp, 386 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (55 pp, 386 K)

Not assessed under the IRIS Program.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.