IRIS

1,1,1-Trichloroethane

CASRN 71-55-6

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (55 pp, 386 K) last updated: 09/28/2007

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Other 2
(Chronic)
Reduced body weight BMDL10 : 2155
mg/kg-day
1000 Low/Medium
Other 7
(Subchronic)
Reduced body weight BMDL10 : 2155
mg/kg-day
300 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (55 pp, 386 K) last updated: 09/28/2007

System RfC (mg/m3) Basis PoD Composite UF Confidence
Hepatic 5
(Chronic)
Liver histopathologic changes NOAEL (HEC): 1553
mg/m3
100 Medium
Hepatic 5
(Subchronic)
Liver histopathologic changes NOAEL (HEC): 1553
mg/m3
100 Medium
Nervous 5
(Short-term)
Performance on neurobehavioral tests LOAEL : 526
mg/m3
100 Medium
Nervous 6
(Acute: 24 hours)
Performance on neurobehavioral tests NOAEL : 950
mg/m3
100 Medium
Nervous 7
(Acute: 8 hours)
Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium
Nervous 7
(Acute: 4 hours)
Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium
Nervous 9
(Acute: 1 hour)
Performance on neurobehavioral tests LOAEL : 950
mg/m3
100 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (55 pp, 386 K) last updated: 09/28/2007

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 1,1,1-trichloroethane provides "inadequate information to assess carcinogenic potential."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (55 pp, 386 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (55 pp, 386 K)

Not assessed under the IRIS Program.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.