IRIS Toxicological Review and Summary Documents for 1,1,1-Trichloroethane (External Review Draft)

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EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,1,1-trichloroethane that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.



1,1,1-Trichloroethane has been used primarily as a solvent for adhesives, in metal degreasing, and in the manufacture of vinylidene chloride. This chemical was formerly used as a food and grain fumigant. 1,1,1-Trichloroethane is one of the compounds addressed by the Montreal Protocol, under which the production and consumption of potentially ozone-depleting substances in the stratosphere are to be phased out. The final phase-out date for 1,1,1-trichloroethane in developed countries was 1996 (with selected exceptions for existing stocks and essential uses) and in developing countries is 2015.

The assessment of 1,1,1-trichloroethane is one of the chemicals in a pilot to explore the inclusion of reference values for less-than-lifetime exposure and other health assessment procedures/features recommended in the Risk Assessment Forum’s 2002 report, A Review of the Reference Dose and Reference Concentration Processes.

1987IRIS assessment of 1,1,1-trichloroethane posted on the IRIS database. (RfD only)
1988Carcinogenicity assessment for 1,1,1-trichloroethane added to the IRIS database. [Related link]
1991RfD withdrawn from the IRIS database.
Feb 2007EPA released the external review draft for public review and comment.
Apr 2007EPA hosted an independent peer review panel workshop to discuss the draft report.
Sep 2007EPA released the final Toxicological Review of 1,1,1-Trichloroethane: in support of the Integrated Risk Information System (IRIS).

Following the External Peer Review, the final assessment will be published on the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2007-1039 (for the docket ID).


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.