Hexachloroethane

CASRN 67-72-1

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 308 K) last updated: 09/23/2011

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
7 x10-4 Urinary Atrophy and degeneration of renal tubules BMDL10 : 0.728
mg/kg-day
1000 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 308 K) last updated: 09/23/2011

RfC (mg/m3) System Basis PoD Composite UF Confidence
3 x10-2 Nervous Neurotoxicity (tremors and ruffled pelt) NOAEL (HEC): 83
mg/m3
3000 Low

Cancer Assessment


Weight of Evidence for Cancer (PDF) (34 pp, 308 K) last updated: 09/23/2011

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), HCE is "likely to be carcinogenic to humans" based on evidence of multiple tumor types in both sexes of rats and mice (NTP, 1989 NCI, 1978).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 308 K)

Oral Slope Factor: 4 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1 x10 -6 per µg/L
Extrapolation Method: The multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Urinary
Tumor type(s): Renal adenomas and carcinomas (combined) (NTP (1989))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 308 K)

Information reviewed but value not estimated.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.