IRIS

Hexachloroethane

CASRN 67-72-1

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 308 K) last updated: 09/23/2011

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary 7 x 10-4 Atrophy and degeneration of renal tubules BMDL10 : 0.728
mg/kg-day
1000 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 308 K) last updated: 09/23/2011

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 3 x 10-2 Neurotoxicity (tremors and ruffled pelt) NOAEL (HEC): 83
mg/m3
3000 Low

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (34 pp, 308 K) last updated: 09/23/2011

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), HCE is "likely to be carcinogenic to humans" based on evidence of multiple tumor types in both sexes of rats and mice (NTP, 1989 NCI, 1978).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 308 K)

Oral Slope Factor: 4 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1 x10 -6 per µg/L
Extrapolation Method: The multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Urinary
Tumor type(s): Renal adenomas and carcinomas (combined) (NTP (1989))



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 308 K)

Information reviewed but value not estimated.

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