CASRN 67-72-1

IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft)

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EPA is releasing the draft report, Toxicological Review of Hexachloroethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.


U.S. EPA. IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/007D, 2011.


Norman Birchfield,  Ph:  703-347-0174,  Email:

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The draft Toxicological Review of hexachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hexachloroethane. Hexachloroethane (C2Cl6) is a colorless, nonflammable, crystalline solid primarily used in the military for pyrotechnic devices. Hexachloroethane has been used as a polymer additive, moth repellant, plasticizer for cellulose esters, insecticide solvent, and for refining aluminum alloys. Hexachloroethane is not commercially distributed in the United States. Exposure to hexachloroethane is primarily occupational, via inhalation and dermal exposure during hexachloroethane manufacturing and metal refining. Exposure may occur in military or civilian personnel working with pyrotechnic devices containing hexachloroethane and via ingestion of contaminated drinking water or fish. Hexachloroethane was identified in Superfund sites.


Date Description
Apr 2010EPA hosted an interagency science consultation on the draft Toxicological Review of Hexachloroethane.
May 2010EPA released the external review draft for public comment. EPA also announced a public listening session on June 16, 2010. [Federal Register May 13, 2010]
Aug 2010EPA announced the external peer review meeting to be held on September 21, 2010. [Federal Register Aug 2, 2010]
Dec 2010EPA released the comments from the external review workshop.
May 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Hexachloroethane.
Sep 2011EPA released the final toxicological review and IRIS Summary for HCE and the interagency review draft with interagency review comments.


This assessment has been loaded into the IRIS Web site and Database.

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