IRIS

Beryllium and compounds

CASRN 7440-41-7

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (51 pp, 284 K) last updated: 04/03/1998

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Gastrointestinal 2 x 10-3 Small intestinal lesions BMD10 : 4.6 x 10-1
mg/kg-day
300 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (51 pp, 284 K) last updated: 04/03/1998

System RfC (mg/m3) Basis PoD Composite UF Confidence
Immune, Respiratory 2 x 10-5 Beryllium sensitization and progression to CBD LOAEL (HEC): 2.0 x 10-4
mg/m3
10 Medium
Immune, Respiratory 2 x 10-5 Beryllium sensitization and progression to CBD LOAEL (HEC): 2.0 x 10-4
mg/m3
10 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (51 pp, 284 K) last updated: 04/03/1998

WOE Characterization Framework for WOE Characterization
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Carcinogenic potential cannot be determined (Oral route) Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Known/likely human carcinogen (Inhalation route) Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • B1; probable human carcinogen. Based on the limited evidence of carcinogenicity in humans exposed to airborne beryllium (lung cancer) and sufficient evidence of carcinogenicity in animals (lung cancer in rats and monkeys inhaling beryllium, lung tumors in rats exposed to beryllium via intratracheal instillation, and osteosarcomas in rabbits and possibly mice receiving intravenous or intramedullary injection), beryllium is reclassified from a B2 (inadequate human data) to a B1 probable human carcinogen (limited human data) using criteria of the 1986 Guidelines for Carcinogen Risk Assessment. Using the 1996 proposed Guidelines for Carcinogen Risk Assessment, inhaled beryllium would be characterized as a "likely" carcinogen in humans, and the human carcinogenic potential of ingested beryllium cannot be determined.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (51 pp, 284 K)

Information reviewed but value not estimated.


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (51 pp, 284 K)

Inhalation Unit Risk: 2.4 x10 -3 per µg/m3
Extrapolation Method: Relative risk
Tumor site(s): Respiratory
Tumor type(s): Lung cancer (Wagoner et al., 1980)


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