Beryllium and compounds

CASRN 7440-41-7

IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft)

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EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Beryllium that when finalized will appear on the Integrated Risk Information System (IRIS) database.


U.S. EPA. IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/009A, 2008.


Amanda Persad,  Ph:  919-541-9781,  Email:

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Beryllium is a light alkaline earth metal used in metal alloys and in high-performance products in the metallurgical, aerospace, and nuclear industries. According to the Superfund database, beryllium is found in over 300 NPL sites. An IRIS Toxicological Review of Beryllium and Compounds was published in 1988 and reassessed in 1998.

This external review draft version only focuses on the cancer assessment and does not re-evaluate posted reference doses or reference concentrations.


Date Description
Nov 1987EPA completed the original beryllium and compounds assessment and posted this in the IRIS database.
Apr 1998Reassessment of oral reference dose and inhalation reference concentration released with cancer reassessment pending forthcoming studies.
May 2008EPA releases assessment that includes updated draft cancer assessment for an external peer review.


This draft has been archived.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2008-0315 (for the docket ID).

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