Tetrachloroethylene

CASRN 127-18-4

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (38 pp, 350 K) last updated: 02/10/2012

RfD (mg/kg-day) System Basis POD UF Confidence
6x10-3 (Chronic)* Multiple* Multiple* Multiple* Multiple* Multiple*
* System-specific RfDs information used to establish RfD

Reference Concentration for Inhalation Exposure (RfC) (PDF) (38 pp, 350 K) last updated: 02/10/2012

RfC (mg/m3) System Basis POD Composite UF Confidence
4 x10-2 (Chronic)* Multiple* Multiple* Multiple* Multiple* Multiple*
* System-specific RfCs information used to establish RfC

Cancer Assessment


Weight of Evidence for Cancer (PDF) (38 pp, 350 K) last updated: 02/10/2012

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Following EPA (2005a) Guidelines for Carcinogen Risk Assessment, tetrachloroethylene is "likely to be carcinogenic in humans by all routes of exposure."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (38 pp, 350 K)

Oral Slope Factor: 2.1 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 6.1 x10 -8 per µg/L
Extrapolation Method: Multistage model (with linear extrapolation from the point of departure (BMDL10), followed by route-to-route extrapolation to the oral route and interspecies extrapolation using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (38 pp, 350 K)

Inhalation Unit Risk: 2.6 x10 -7 per µg/m3
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMCL10), followed by extrapolation to humans using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)


Organ/System-Specific RfDs:

System Basis RfD (mg/kg-day) POD UF Confidence
Neurological Neurotoxicity (reaction time, cognitive effects) 0.0097 LOAEL: 9.7 mg/kg-day 1000 Medium
Neurological, Ocular Neurotoxicity (color vision) 0.0026 LOAEL: 2.6 mg/kg-day 1000 Medium

Organ/System-Specific RfCs:

System Basis RfC (mg/m3) POD UF Confidence
Neurological Neurotoxicity (reaction time, cognitive effects) 0.0056 LOAEL: 56 mg/m3 1000 Medium
Neurological, Ocular Neurotoxicity (color vision) 0.0015 LOAEL: 15 mg/m3 1000 Medium

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