Tetrachloroethylene (Perchloroethylene)

CASRN 127-18-4

IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft)

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EPA is releasing the draft report, Toxicological Review of Tetrachloroethylene (Perchloroethylene), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.


U.S. EPA. IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/011D, 2011.

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Tetrachloroethylene (perc) is a chemical solvent widely used in dry cleaning, metal degreasing, the manufacture of some consumer products and other chemicals. It is a prevalent groundwater and drinking water contaminant, is present in hundreds of Superfund sites, and has been detected in the air in and around dry cleaning facilities and nearby residences.


Date Description
05-Jul 2008EPA released the external review draft of the IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) for public review and comment.
07-Aug 2008EPA hosted a public listening session as announced in the July 29, 2008 Federal Register Notice.
08-Nov 2008National Academy of Sciences (NAS) conducted an external peer review meeting to review the draft document on Nov. 13-14, 2008 in Washington DC as announced in the October 16, 2008 Federal Register Notice
09-Jan 2009NAS held their second external review meeting to discuss the draft peer review report on Jan 29-30, 2009, in Washington DC.
11-Apr 2009NAS announced a third external review meeting to discuss the draft peer review report on Apr 2-3, 2009, in Irvine, CA.
12-Feb 2010The National Research Council releases the Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. [NAS Press Release February 9, 2010]
13-Aug 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review and draft IRIS Summary for Tetrachloroethylene (Perchloroethylene).
14-Oct 2011EPA hosted a second interagency science discussion as follow-up to the August discussion.
15-Feb 2012EPA released the final IRIS Toxicological Review and IRIS Summary for Tetrachloroethylene (Perchloroethylene), and the Interagency review draft, the interagency review comments, and EPA's response to major interagency comments.


This assessment has been loaded into the IRIS Web site and Database.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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