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Environmental Assessment

IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)

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On September 9, 2011, the Toxicological Review of 1,4-Dioxane (inhalation) (External Review Draft) was posted for external peer review and public comment. Subsequently, the Toxicological Review and IRIS Summary were reviewed internally by EPA and by other federal agencies and Executive Office of the President before final public release. Based on the 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and the Executive Office of the President will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science discussion draft of the IRIS Toxicological Review of 1,4-dioxane (with inhalation update) and the draft IRIS Summary are posted on this site.

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Samantha J. Jones
  • by phone at:   703-347-8580
  • by email at:  jones.samantha@epa.gov


1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. The 2010 oral assessment has now been updated with additional information regarding 1,4-dioxane toxicity following exposure via inhalation resulting in the 2013 1,4-dioxane assessment (with inhalation update).


Aug 2010EPA released the final oral toxicity assessment of 1,4-dioxane on the IRIS Web site.
May 2011EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.
Sep 2011EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
Jul 2013EPA initiated the final agency review and interagency science discussion on the draft Toxicological Review of 1,4-Dioxane (with inhalation update) and draft IRIS Summary.
Sep 2013EPA released the final IRIS Toxicological Review of 1,4-Dioxane (with inhalation update) and IRIS Summary for 1,4-Dioxane along with the interagency science discussion draft, interagency comments, and EPA’s response to interagency comments.

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This assessment has been loaded into the IRIS Website and Database.


U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/003D, 2013.


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