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Environmental Assessment

Perspectives on the Application of Mechanistic Information in Chemical Hazard and Dose-Response Assessments

Report Information

This overview summarizes several EPA Assessment publications reviewing approaches for applying mechanistic information in human health risk assessment and exploring opportunities for progress in this area.

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Kathryn Guyton
  • by phone at:   703-347-8562
  • by email at:  guyton.kate@epa.gov

Background

EPA initiated a multidisciplinary project to examine methods for applying mechanistic information in human health risk assessment, to identify challenges, and to suggest and explore opportunities for improvement. Motivations included the significant ability of mechanistic data to inform chemical hazard and dose-response assessments. This project examined approaches for interpreting observed effects in laboratory animals and their human relevance based on hypothesized modes of action. In addition, a critical aspect of the work was to explore issues pertinent to toxicity-pathway based risk assessment. This report summarizes published project results.

History/Chronology

2008 - 2009Project results are published in peer-reviewed journals.
Sep 2010EPA releases this summary report.

Citation

U.S. EPA. Perspectives on the Application of Mechanistic Information in Chemical Hazard and Dose-Response Assessments. U.S. Environmental Protection Agency, Washington, DC, 2010.

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